Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
SUSAN R ROSS · UNIVERSITY OF ILLINOIS AT CHICAGO · 2024 · $480,006 — New world hemorrhagic fever arenaviruses (NWAs), such as Junín virus, are rodent-transmitted viruses that cause ~30% mortality when they zoonose into humans. The mechanism by the NWAs induce disease is still not certain, although it likely includes induction of high levels of cytokines by infected s…
Jiani Yu · WEILL MEDICAL COLL OF CORNELL UNIV · 2024 · $126,590 — PROJECT SUMMARY/ABSTRACT CMS expanded telehealth coverage for Medicare beneficiaries in March 2020, removing multiple barriers to the provision of telehealth in skilled nursing facilities (SNFs). While telehealth has the potential to reduce potentially avoidable hospital readmissions and emergency d…
GRACE X. MA · TEMPLE UNIV OF THE COMMONWEALTH · 2024 · $793,566 — Abstract Asian Americans (AAs) represent approximately 7% of the U.S. population but account for over half of all Hepatitis B virus (HBV) infections nationally. Among the estimated 2.4 million Americans living with HBV, 58% are AAs, who exhibit the highest HBV prevalence across U.S. population group…
ALAN THOMAS JOHNSON · HAWAII BIOTECH, INC. · 2024 · $204,860 — Abstract/Project Summary Along with the many benefits of a global economy hides the ever-present risk for the world wide spread of infectious disease. While significant outbreaks of the flu in the recent past involving millions of individuals could be contained, the emergence and rapid spread of th…
Jonathan Drew Schaefer · VANDERBILT UNIVERSITY · 2024 · $158,719 — PROJECT SUMMARY/ABSTRACT Substance use is a major public health concern that disproportionately affects individuals from lower socioeconomic status (SES) backgrounds. Although part of this association is attributable to downward socioeconomic mobility among individuals who develop problematic patte…
Matthew Eisenberg · JOHNS HOPKINS UNIVERSITY · 2024 · $673,232 — ABSTRACT Public health disasters and the drug addiction and overdose epidemic are among the foremost public health issues facing the United States. Disaster-related disruptions to drug addiction treatment and overdose prevention services can be life-threatening to people with drug addiction. Public …
Bo Wang · UNIV OF MASSACHUSETTS MED SCH WORCESTER · 2024 · $237,441 — The importance of – and difficulty in – sustaining implementation, with fidelity, of effective HIV interventions is well recognized. Our research partnership of >20 years in The Bahamas, a country disproportionately impacted by the HIV epidemic, positions us well to explore sustainability of evidenc…
Franco Rafael D'Alessio · JOHNS HOPKINS UNIVERSITY · 2024 · $787,156 — Pneumonia (PNA) is one of the leading causes of death worldwide. PNA can result in devastating acute inflammatory injury in the lung manifesting in acute respiratory distress syndrome (ARDS). Current treatments for PNA have focused on the pathogens, but do not target excessive lung inflammation elic…
Jeremiah James Faith · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2024 · $324,480 — PROJECT SUMMARY The treatment of recurrent Clostridioides difficile infection (rCDI) by fecal microbiota transplantation (FMT) is the defining success amongst therapeutics aimed to manipulate the microbiome with cure rates typically exceeding 80% of recipients. This success has facilitated numerous …
YONG-HUI ZHENG · UNIVERSITY OF ILLINOIS AT CHICAGO · 2024 · $399,750 — HIV-1 envelope (Env) glycoprotein (gp) 160 belongs to class I fusion proteins that are also expressed by other highly pathogenic human viruses including influenza A viruses (IAV), Ebola viruses (EBOV), and coronaviruses (CoV) such as SARS-CoV (SARS1), MERS, and SARS-CoV-2 (SARS2). They build spikes …
Susan H Busch · YALE UNIVERSITY · 2024 · $579,537 — PROJECT SUMMARY Alcohol Use Disorder (AUD) is one of the leading causes of preventable death in the US and has high personal and societal costs. Despite the widespread acceptance that evidence-based treatments exist for AUD, less than one in nine individuals with AUD report receiving specialty treat…
Emily S Day · UNIVERSITY OF DELAWARE · 2024 · $408,005 — PROJECT SUMMARY/ABSTRACT The Day Lab engineers nanoparticles (NPs) with unique physicochemical properties to transform the treatment of various diseases and elucidates how architecture impacts function by studying nano/bio interactions from the subcellular to whole organism level. The NPs we develo…
Ella Thomas Vardeman · CUNY GRADUATE SCH AND UNIV CTR · 2024 · $44,817 — Proposal Abstract Approximately 55% of the world’s population lives in cities, and the United Nations estimates that this number will rise to 68% by 2050. Urban ethnobotany, the study of people’s traditional knowledge and use of plants in cities, is increasingly important as people adapt their cultu…
Jessica L. Krok-Schoen · OHIO STATE UNIVERSITY · 2024 · $196,875 — ABSTRACT Accounting for more than 60% of cancer survivors, older (≥65 years) cancer survivors, have a 2- to 5-fold risk of physical function impairment, compared to cancer-free controls. Physical function impairment has multiple deleterious health effects including poor health-related quality of lif…
Sylia Wilson · UNIVERSITY OF MINNESOTA · 2024 · $339,626 — PROJECT SUMMARY Substance use is a major public health concern that disproportionately affects individuals from socioeconomically disadvantaged backgrounds. We propose the mechanistic hypothesis that childhood socioeconomic disadvantage and other aspects of social inequality leads to neurobehavioral…
Benjamin Goldman-Israelow · YALE UNIVERSITY · 2024 · $193,828 — Project Summary/Abstract To date, the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-Cov-2) has caused over 32 million cases of coronavirus disease (COVID-19), with ~1 million associated deaths. Multiple vaccine trials have begun in an effort to stop this pandemic, yet the correlates of viral…
Anthony W.G. Burgett · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · 2024 · $17,416 — The current COVID-19 crisis starkly illustrates the need to develop new modalities for the therapeutic treatment of pathogenic single-stranded RNA (ssRNA) viruses, including against novel viruses that have yet to emerge. Human oxysterol-binding protein (OSBP) has recently been determined to be a cri…
Anna-Sophie Rommel · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2024 · $716,474 — SUMMARY The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has infected over 233 million people globally. The US alone has reported ~126,000 coronavirus disease-19 (COVID-19) cases in pregnant individuals, not including many asymptomatic and unconfirmed cases. Thus, potentially million…
SARASWATI SUKUMAR · JOHNS HOPKINS UNIVERSITY · 2024 · $544,861 — ABSTRACT Colorectal cancer (CRC) is diagnosed at advanced stages in many low- and middle-income countries (LMICs). The lack of knowledge of CRC signs and symptoms by patients and community health practitioners frequently leads to delayed presentation with Stage 3-4 disease. This initial delay, paire…
Robert G Weaver · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · 2024 · $605,896 — Summer is a period of accelerated BMI gain for children (5-12yrs). Studies show that virtually all increases in BMI occur during the summer, no matter children’s’ weight status (i.e., normal weight, overweight, or obese) at summer entry. Our research team recently developed the Structured Days Hypot…