Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Dustin T Duncan · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2024 · $715,456 — PROJECT SUMMARY Black gay, bisexual and other men who have sex with men (MSM) face a disproportionate burden of HIV. Focused, high-coverage PrEP in populations heavily impacted by HIV, such as Black MSM, could rapidly reduce new HIV acquisition rates; however, its uptake among at-risk populations, e…
Yi Ren · VANDERBILT UNIVERSITY · 2024 · $515,125 — Project Summary In all eukaryotic cells, export of mRNA from the nucleus to the cytoplasm is an essential step in gene expression. As such, mRNA nuclear export is fundamental for all cellular activities and has been linked to various diseases when it is dysregulated, such as in cancer, neurological …
Gayenell Smith Magwood · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · 2024 · $648,398 — PROJECT SUMMARY/ABSTRACT Persons of color (POC) from underserved communities are at increased risk of COVID-19 related morbidity and mortality due to a variety of social and structural health determinants (SSDH; e.g., barriers to health care access) and higher rates of underlying chronic diseases su…
ABRAHAM REICHENBERG · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2024 · $636,347 — PROJECT SUMMARY Individuals diagnosed with schizophrenia and related psychotic disorders (SZ) exhibit a markedly elevated risk of premature mortality, with a 10–20-year shorter lifespan relative to the general population. Increased mortality rates in SZ are largely attributable to the early manifest…
William A Petri · UNIVERSITY OF VIRGINIA · 2024 · $598,766 — PROJECT SUMMARY Significance: Mothers and children in Bangladesh and other low-mid income countries suffer disproportionately from maternal and infant malnutrition, neonatal mortality from diarrhea and respiratory infections, and maternal mortality from childbirth, vaccine failure and impaired child…
Vladimir Denic · HARVARD UNIVERSITY · 2024 · $575,852 — Abstract My lab currently has two main areas of interest: 1) a new chaperone system (eFOLD) that enables biogenesis of eukaryotic translation elongation factor 1 alpha (eEF1A); 2) endoplasmic reticulum (ER) and peroxisome degradation by selective autophagy. Errors in eEF1A biogenesis result in rapid…
Leslie I. Katzel · UNIVERSITY OF MARYLAND BALTIMORE · 2024 · $385,773 — 7. Project Summary: Overall The theme of the UM-OAIC is enablement defined as the restoration of function in those with impairments and the prevention or delay of further progression in those who are already disabled. The overarching mission of the UM-OAIC is to develop, implement, and evaluate reha…
Rhiju Das · STANFORD UNIVERSITY · 2024 · $250,000 — PROJECT SUMMARY The continuing discoveries of RNAs and their critical roles in cellular and viral machinery are inspiring novel antibacterial, antitumor, antiviral, and genome-editing therapies based on disabling, manipulating, and repurposing the RNAs involved. Unfortunately, our poor biophysical u…
Svetla Stefanova Slavova · UNIVERSITY OF KENTUCKY · 2024 · $167,078 — ABSTRACT: The opioid epidemic continues to plague the United States. Unreliable and slow data systems pose a continuing challenge to the public health response. There is a paucity of real-time data that can be used to detect or forecast increases in opioid overdoses and coordinate timely community r…
Darby E. Saxbe · UNIVERSITY OF SOUTHERN CALIFORNIA · 2024 · $48,837 — PROJECT SUMMARY The COVID-19 pandemic has had sweeping effects on pregnant women and their partners. The need to adhere to social distancing guidelines has altered the social connectedness of expectant parents, with effects on stress, loneliness, reduced access to in- person prenatal care, and chil…
Edwin Duncan Charlebois · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2024 · $235,000 — SUMMARY Significant disparities in preventing, treating, and managing multiple chronic diseases exist along intersecting racial, cultural, socio-economic, and vulnerable population contextual lines. Meaningful community engagement and culturally informed multilevel approaches are required to effecti…
CYNTHIA E DUNBAR · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · 2024 · $2,130,169 — My research group has worked for over 32 years in the laboratory and in the clinic to develop safe and effective gene therapies directed at hematopoietic stem and progenitor cells (HSPC). In the rhesus macaque model, shown to be the only predictive assay for human clinical results, we have focused o…
Henry Masur · CLINICAL CENTER · 2024 — The project is led by DCPFAP investigators with the active collaboration of NIMH, NIDA, NINDS, and NIAID. For the first study, a phase I study carried out at the NIH Clinical Center, investigators met with FDA to determine what studies needed to be done prior to a Phase II study. An interaction st…
Robert Brosh · NATIONAL INSTITUTE ON AGING · 2024 · $352,051 — Point mutations in the SARS-CoV-2 genome have potential consequences for the novel coronavirus life cycle, leading to alterations in its ability to replicate or transcribe its genome with an impact on transmission and virulence. Therefore, characterization of the cis- and trans-activating factors re…
DIANE L. DAMIANO · CLINICAL CENTER · 2024 — Data collection for Objective 2 was quite active before the COVID pandemic. During that time period, our genetics collaborator accepted a position at Johns Hopkins University and was no longer able to collaborate with us. We were able to collect data on a few more participants before the genetics la…
Sharon A. Savage · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · 2024 · $407,021 — Infection by the acute respiratory syndrome coronavirus 2 (SARS-CoV-2) results in the infectious disease syndrome known as coronavirus disease 2019 (COVID-19). SARS-CoV-2 was originally described in late 2019 in Wuhan, China and has since spread throughout the world causing the 2019-2020 COVID-19 pa…
MARC NICKLAUS · DIVISION OF BASIC SCIENCES - NCI · 2024 · $423,890 — The SAVI Project is based on: (a) a set of transforms with rich chemical context annotation including functional group reactivity data; (b) a set of building blocks from Enamine (c) the chemoinformatics toolkit CACTVS with custom development (Xemistry GmbH, Germany) The transforms are a set of more …
Marc Ghany · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · 2024 · $614,571 — Summary: Globally there are an estimated 254 million persons infected with hepatitis B virus (HBV). In the United States, there are 1.25 million individuals with chronic HBV infection. Chronic HBV infection results in >1 million deaths annually worldwide from complications of cirrhosis and hepatoce…
Richard Proia · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · 2024 · $3,503,685 — Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection causes injury to multiple organ systems, including the brain. SARS-CoV-2s neuropathological mechanisms may include systemic inflammation and hypoxia, as well as direct cell damage resulting from viral infections of neurons and gl…
Susan Pierce · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2024 · $2,631,859 — Understanding B cell responses to membrane associated antigens A fundamental feature of B cell responses to antigen in secondary lymphoid organs (SLOs) in vivo is the presentation of the antigen on the surface of FDCs. We compared the responses of human B cells to antigen associated with membranes,…