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9873 documents

Improving Glycemia & Reducing Diabetes Distress in Adolescents & Young Adults with T1D

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

KOREY K HOOD · JOSLIN DIABETES CENTER · 2024 · $646,831 — PROJECT SUMMARY/ABSTRACT Adolescents and young adults (AYA) with type 1 diabetes (T1D) are especially at risk for missed diabetes visits and suboptimal self-care behaviors, as evidenced by their poor glycemic control with very high A1c levels. Further, diabetes distress is common in AYA with T1D and…

Supporting health equity with bias-free pulse oximetry

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Mariana Gross Figueiro · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2024 · $652,377 — Project Summary Pulse oximeters are essential for physicians’ diagnosis and monitoring of respiratory anomalies in patients. During the COVID-19 pandemic, their importance has grown because pulse-oximeter measurements of hypoxemia have become the major indication for hospitalizing patients. Clinical…

Real-time predictive modeling for public health departments to control infectious diseases

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Nathan Lo · STANFORD UNIVERSITY · 2024 · $463,200 — PROJECT SUMMARY Public health departments increasingly use predictive modeling to guide decisions and resource allocation for the control of infectious diseases in the United States, especially during the COVID-19 pandemic. These novel predictive models offer promise to better identify high-risk po…

Mechanisms of antiviral immunity and tolerance in the intestinal epithelium of Jamaican Fruit Bats

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Diane Bimczok · MONTANA STATE UNIVERSITY - BOZEMAN · 2024 · $181,250 — Summary The gastrointestinal (GI) tract is a major target organ for viral infection in bats, but infections rarely cause typical symptoms of viral enteritis such as diarrhea. The long-term goal of our project is to understand the specific innate immune response mechanisms of the intestinal epitheli…

Role of Macrophages in CBD mediated attenuation of SEB-induced ARDS

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Kiesha Wilson · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · 2024 · $248,958 — PROJECT SUMMARY/ABSTRACT The virus, SARS-CoV-2 has caused COVID-19 and claimed the lives of over 240,000 Americans and 1,270,000 people worldwide. Severe cases of the disease leads to Acute Respiratory Distress Syndrome (ARDS), sepsis and can be fatal due to pulmonary inflammation and destruction of…

Structural, Functional, and Neurobehavioral Consequences of Adolescent COVID-19

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Meghann Ryan · UNIVERSITY OF MARYLAND BALTIMORE · 2024 · $37,490 — Project Summary In the USA, SARS-CoV-2 has infected more than 16 million children and adolescents, who are undergoing critical periods of brain development when higher cognitive abilities are acquired, and mental illnesses typically emerge. Autopsy, blood, and CSF studies during acute COVID-19 repor…

Human Herpesvirus 6B in Myalgic Encephalomyelitis / Chronic Fatigue Syndrome pathogenesis: temporal analysis of viral reactivation and immunity to elucidate cause vs effect

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Jackie Cliff · LONDON SCH/HYGIENE & TROPICAL MEDICINE · 2024 · $510,930 — PROJECT SUMMARY / ABSTRACT Our research project, entitled “Human Herpesvirus 6B in Myalgic Encephalomyelitis / Chronic Fatigue Syndrome pathogenesis: temporal analysis of viral reactivation and immunity to elucidate cause vs effect”, aims to validate or refute the findings of our preliminary study o…

Point-of-Care RT-PCR System to Inform COVID-19 and Respiratory Illness Decisions

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Frederick R Haselton · VANDERBILT UNIVERSITY · 2024 · $762,178 — Project Summary The ongoing COVID-19/SARS-CoV-2 pandemic highlights the need for simple, rapid, and cost-effective testing for respiratory infections at the point-of-care, including physician’s offices, urgent-care settings, ambulatory procedural centers, and low-resource environments. The need is …

Support for the International Society of Electrophysiology and Kinesiology Congress

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

ERIC JON PERREAULT · NORTHWESTERN UNIVERSITY · 2024 · $10,830 — PROJECT SUMMARY This proposal seeks funding to support increased participation from a diverse group of scientists, researchers, and clinicians and to enhance professional development programming targeted towards early career researchers (ECRs) during the congresses of the International Society of E…

Trace Elements in Biology and Medicine

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Thomas Benedict Bartnikas · FEDERATION OF AMER SOC FOR EXPER BIOLOGY · 2024 · $28,250 — PROJECT SUMMARY The 2024 FASEB Conference on Trace Elements in Biology and Medicine will take place in Melbourne, Florida from June 12 – 16, 2024. This conference, the 17th iteration of this biennial meeting since 1983, is designed to bring together a diverse group of researchers to share and discus…

Telemedicine Integrated into Pediatric Primary Care & Child Outcomes

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Alexander Gabriel Fiks · CHILDREN'S HOSP OF PHILADELPHIA · 2024 · $647,634 — During the summer of 2021, 80% of pediatricians reported using live audio-video telemedicine in the prior month, up from 16% of pediatricians with telemedicine experience just four years before. The child health workforce now actively uses telemedicine to care for children, but lacks evidence to …

Characterization of Persistent COVID-19

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Amy K Barczak · BRIGHAM AND WOMEN'S HOSPITAL · 2024 · $846,387 — PROJECT SUMMARY Immunosuppressed individuals are increasingly recognized as a focal point of the COVID-19 epidemic. They are at increased risk of chronic COVID-19 infection, therapeutic treatment failure, severe disease and COVID-19 mortality. Evidence is also emerging that they may also be drivers …

Studying synaptic transmission under opioid exposure using hiPSC-derived midbrain model and hyperspectral fluorescence lifetime imaging

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Stephanie Kristin Seidlits · UNIVERSITY OF TEXAS AT AUSTIN · 2024 · $221,843 — Project Summary There is an urgent need to address the current public health crisis of opioid abuse and overdose deaths through development of effective treatments for opioid use disorder (OUD) and non-addictive therapeutics to manage pain. Ultimately, achievement of these goals would be greatly fac…

Cell death pathway leading to vacuole permeabilization

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

J. Marie Hardwick · JOHNS HOPKINS UNIVERSITY · 2024 · $245,625 — PROJECT SUMMARY Programmed cell death (self-induced) is intrinsic to cellular life, including unicellular species. However, cell death research has focused primarily on animal models to understand cancer, degenerative disorders, and developmental processes. In contrast, there is comparably little kn…

Early life B cell responses and inflammation following SARS-CoV-2 infection

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Genevieve Giny Fouda Amou ou · WEILL MEDICAL COLL OF CORNELL UNIV · 2024 · $852,895 — Abstract As of March 2021, SARS-CoV-2 has caused more than 50 million infections and 2 million deaths, constituting an unprecedented pandemic in the modern world. While infected individuals rapidly develop IgG responses against the viral Spike after infection, some studies have indicated that indivi…

Cancer Epidemiology Cohort in Male Health Professionals

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Lorelei Mucci · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · 2024 · $1,405,685 — The goal of this competing renewal application is to support the core infrastructure and follow-up of the Health Professionals Follow-up Study (HPFS), a cancer epidemiology cohort of 51,529 U.S. male health professionals age 40 to 75 years at baseline in 1986. This cohort is unique in its focus on m…

Communication quality during family meetings in the intensive care unit: how does quality impact health outcomes?

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Allison M Scott · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · 2024 · $590,414 — ABSTRACT When poor communication between clinicians and family members of ICU patients, disparities related to social determinants of health (SDOH), and a heightened distrust of healthcare professionals all coalesced during the COVID-19 pandemic, “the perfect storm” emerged. Improving communication …

Oklahoma Shared Clinical and Translational Resources

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

JUDITH A JAMES · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · 2024 · $3,999,999 — The primary mission of the Oklahoma Shared Clinical and Translational Resources (OSCTR) is to improve health by catalyzing clinical and translational research (CTR) that addresses the top health concerns experienced in the state. The OSCTR integrates health professionals, investigators, and scientif…

The Center for Advancing Point of Care in Heart, Lung, Blood and Sleep Diseases

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

BRYAN O BUCHHOLZ · UNIV OF MASSACHUSETTS MED SCH WORCESTER · 2024 · $1,732,375 — Project Summary/Abstract – Overall Core American healthcare is rapidly evolving to a state where efficiency, quality and patient satisfaction are dominant drivers. Several trends are driving fundamental changes in health care: 1) an expanding scope of virtual care and telemedicine, accelerated by th…

Immune Modulation During Acute Lyme Disease Infection as the Result of Aberrant Immunoglobulin Glycosylation

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Mary Ann Comunale · DREXEL UNIVERSITY · 2024 · $187,033 — Abstract: Lyme disease (LD) leads to lifelong health problems if standard antibiotic therapy is not initiated during the first 2-3 weeks after infection. Diagnosis for LD currently relies on seroconversion and is unreliable during acute disease. Cases of suspected acute LD should be confirmed using …