Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Alexander Sandhu · STANFORD UNIVERSITY · 2024 · $137,305 — PROJECT SUMMARY/ABSTRACT Heart failure causes over 80,000 deaths and $30 billion in spending annually, yet therapies that improve survival and reduce morbidity are underutilized. Insufficient healthcare quality and high costs sparked the development of value-based payment programs, such as Medicare’…
Stephanie Crowley McWilliam · RUSH UNIVERSITY MEDICAL CENTER · 2024 · $489,568 — PROJECT SUMMARY A majority of older adolescents in the U.S. are chronically sleep deprived, getting 1- 2 h less sleep than recommended. The circadian (~24-h) system shifts later (delay) with the progression of puberty; this shift contributes to late sleep onsets in older adolescents. Early school st…
KORNELIA POLYAK · DANA-FARBER CANCER INST · 2024 · $1,007,771 — PROJECT SUMMARY: Breast cancer is the most common cancer and the leading cause of cancer deaths in women world- wide. While targeted and immune therapies have improved patient outcomes, a significant fraction of patients fail to respond to treatment and die of their disease. Most of these therapeuti…
Humam Kadara · UNIVERSITY OF TX MD ANDERSON CAN CTR · 2024 · $593,147 — PROJECT SUMMARY A significant fraction of lung adenocarcinomas (LUADs) in lifetime smokers harbor somatic mutations in the KRAS oncogene (KM-LUADs). Due to enhanced screening, KM-LUAD is increasingly being detected at earlier pathological stages, thus posing a growing public health burden that warra…
Trenette Clark Goings · UNIV OF NORTH CAROLINA CHAPEL HILL · 2024 · $377,477 — PROJECT SUMMARY The biracial population is the second-fastest growing demographic group in the US. Biracial adolescents also have higher risks of substance use as well as violent behavior, school problems, and poor physical and mental health than many of their monoracial peers. However, little is k…
STELLA AGUINAGA BIALOUS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2024 · $633,384 — ABSTRACT Tobacco use is the leading preventable cause of death and is responsible for a third of cancer deaths in the US. Tobacco-induced diseases and mortality are not equally distributed. Racial, ethnic, gender and sexual orientation minorities, as well as those living below the poverty line and w…
DAVID E MOORMAN · GORDON RESEARCH CONFERENCES · 2024 · $25,000 — SUMMARY/ABSTRACT The prefrontal cortex (PFC) is involved in all aspects of cognition and behavior and has established roles in all forms of mental illness and substance use disorders. The PFC has been studied intensely over the past four decades. Interest in studies of the PFC in animal models has g…
Matthew Blake Greenblatt · WEILL MEDICAL COLL OF CORNELL UNIV · 2024 · $606,973 — Project Summary Approximately .5% of children are born missing a limb, and 2.1 million in the US alone are living with limb loss. Current management for these patients largely relies on the use of prostheses, however most prosthetic use is marked by significant patient dissatisfaction due to functio…
Kathryn Amy Cross · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2024 · $242,055 — PROJECT SUMMARY A promising strategy to improve neuromodulation therapies (e.g. deep brain stimulation) in Parkinson’s Disease (PD) is to develop stimulation paradigms that target specific neural signals. Most previous work has aimed to identify and reduce pathologic signals. An unexplored alternat…
Radhika Subramanian · MASSACHUSETTS GENERAL HOSPITAL · 2024 · $336,000 — ABSTRACT The Hedgehog (Hh) signaling pathway is a major intercellular signaling pathway important for embryonic development and adult tissue homeostasis. Errors in Hh signaling are linked to several newborn birth defects such as skeletal malformations and craniofacial defects, and associated with mu…
DANE B. COOK · WM S. MIDDLETON MEMORIAL VETERANS HOSP · 2024 — Chronic multi-symptom illnesses (CMI) are complex and poorly understood diseases principally characterized by fatigue, pain, and problems with cognitive function. For Veterans, these diseases are collectively referred to as Gulf War Illnesses (GWI) and affect ~250,000 Gulf War Veterans (GVs) (25-35%…
Nathan A Dahl · UNIVERSITY OF COLORADO DENVER · 2024 · $189,896 — PROPOSAL SUMMARY Diffuse intrinsic pontine gliomas (DIPGs) are aggressive brainstem tumors in children with no curative therapies available. DIPGs are canonically driven by recurrent mutations in the histone 3 gene (H3K27M). This substitution imparts broad dysregulation of the histone post-translati…
Karen Reue · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2024 · $1,467,135 — Overall SUMMARY The objective of our SCORE on “Sex Differences in Cardiometabolic Health and Disease” is to identify factors that determine sex-specific cardiometabolic disease risk, which may lead to better diagnosis and treatment for both sexes. A unique feature of our program is the investigatio…
Peter Leif Bergsagel · MAYO CLINIC ARIZONA · 2024 · $2,098,348 — PROJECT SUMMARY/ABSTRACT The Mayo Clinic Multiple Myeloma SPORE (SPORE) is a dynamic, productive, translational cancer research program based at all three Mayo Clinic sites (Rochester MN, Jacksonville FL, Phoenix AZ), now with input from the Princess Margaret Cancer Centre in Toronto, Ontario. From …
XIAOMIN FAN · AVANTGEN, INC. · 2024 · $1,398,552 — Abstract Patients diagnosed with myelodysplastic syndrome (MDS) face a challenging treatment landscape, with limited options consisting mainly of blood transfusions and hypomethylating agents. This therapeutic regimen has remained stagnant for the past two decades. Adding to the complexity, a signif…
Jake J. Hays · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2024 · $36,536 — PROJECT SUMMARY. The economy and the family—two social institutions that strongly affect health and well-being in the US—have undergone profound change in the last half-century. The economy changed through the stagnation of male wages, declining manufacturing jobs and rising service sector employmen…
Dustin T Duncan · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2024 · $774,324 — PROJECT SUMMARY To address the aims of the proposed research and RFA-HL-21-018, we will use a syndemics and multi-level approach to investigate relationships between sleep and HIV treatment outcomes and behaviors (e.g., viral suppression and retention in care) cross-sectionally and longitudinally am…
Erin Flaherty · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2024 · $131,733 — PROJECT SUMMARY During development, individual neurons extend highly branched neurites that innervate the surrounding territory with minimal overlap. In mammals, the clustered protocadherins (Pcdh) provide each neuron with a unique cell specific identity required for self-identification and self-av…
Jacklyn Donna Foley · MASSACHUSETTS GENERAL HOSPITAL · 2024 · $195,772 — PROJECT SUMMARY In this K23 proposal, I outline a comprehensive five-year training program that will prepare me for the transition to an independent, R01 level investigator capable of developing novel, feasible, and scalable integrative behavioral interventions to reduce psychological and cardiovasc…
Mohammed Adnan Mohammed Hanif Qureshi · NEMALIFE INC. · 2024 · $322,070 — Project Abstract Alcohol use disorders (AUDs) are globally prevalent neurobehavioral disorders where individuals consume excessive alcohol despite its adverse effects on their lives. The global incidence of deaths related to AUDs was estimated at 3 million in 2016, while in the US, 140,000 deaths an…