Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Michael S. Saag · UNIVERSITY OF ALABAMA AT BIRMINGHAM · 2024 · $6,404,188 — PROJECT SUMMARY / ABSTRACT Modern antiretroviral treatments alter the progression of disease, enabling the majority of HIV+ individuals to live near-normal life spans. Yet, ~ 20% of patients in the US fail to achieve long-term virologic suppression, and even for those who do, there remains the threa…
Jorge Luis Gamboa · VANDERBILT UNIVERSITY MEDICAL CENTER · 2024 · $623,768 — Project Summary End-stage renal disease (ESRD), the final stage of chronic kidney disease (CKD), requires renal replacement therapy such as hemodialysis. Every year more than 100,000 individuals start hemodialysis. Patients undergoing hemodialysis are at increased risk of frailty and sarcopenia. Fr…
Y. Xian Ho · DIMAGI, INC. · 2024 · $874,937 — PROJECT SUMMARY Substance use disorder (SUD) is a significant public health challenge, and it has been estimated that its effects on healthcare, work productivity, and criminal justice costs the US over $600 billion annually. Engagement with the clinical care team is critical to an individual’s path…
Joseph de Rutte · PARTILLION BIOSCIENCE CORPORATION · 2024 · $731,568 — ABSTRACT Monoclonal antibody therapies now account for the majority of blockbuster drugs and the number and breadth of diseases tackled by this therapeutic modality are expected to rapidly grow in the coming decade. However, existing discovery technologies force users to choose between performance a…
Maria Mavrikaki · BETH ISRAEL DEACONESS MEDICAL CENTER · 2024 · $855,196 — SUMMARY. This proposal is in response to PAR-21-038: Stephen I. Katz Early Stage Investigator Research Project Grant. Aging is a major risk factor for the development of cognitive deficits and neurodegenerative diseases. Understanding the exact molecular mechanisms of brain aging and accelerated bra…
ADRIENNE E SHAPIRO · UNIVERSITY OF WASHINGTON · 2024 · $168,574 — ABSTRACT International and South African guidelines recommend TB preventive therapy (TPT) for people with HIV (PWH) and other people at high risk for TB, including close contacts of people with TB. Despite the evidence for reduced morbidity and mortality for people with HIV (PWH) who receive TPT, an…
Sarah M Flood · UNIVERSITY OF MINNESOTA · 2024 · $659,258 — Project Summary/Abstract This proposal seeks continued funding to expand and improve IPUMS CPS, an essential data resource for research on population health and child well-being in the United States. IPUMS CPS streamlines access and reduces technical barriers to analyzing data from the Current Popul…
Bastiaan Driehuys · DUKE UNIVERSITY · 2024 · $744,470 — Project Summary/Abstract Dyspnea (shortness of breath) is among the most common reasons for seeking medical attention. It has a prevalence rivaling chronic pain and accounts for 10% of emergency room visits. Dyspnea workups involve extensive diagnostic testing, with high cost, and a slow time to dia…
Kenneth Hoehn · DARTMOUTH COLLEGE · 2024 · $249,000 — Human B cells play a fundamental role in the adaptive immune response to infection, development of protective immunity from vaccination, and pathology of many autoimmune diseases. Central to all of these processes are migration of B cells among different tissues and differentiation of B cells into f…
CYNTHIA A. BRANDT · YALE UNIVERSITY · 2024 · $1,360,000 — Project Summary / Abstract The Pain Management Collaboratory Coordinating Center (PMC3) will continue to provide national leadership for the NIH-DOD-VA Pain Management Collaboratory (PMC), building on its successes over the original six-year period of funding. Three key aims are to: 1) develop, adap…
Raghuveer Basude · MEDFREE, INC. · 2024 · $275,530 — Project Summary The MEDFREE® Valve Repair System will innovatively improve upon the current market leading MitraClip device, while leveraging and building on the proven Transcatheter Edge-to-Edge Repair technique. We aim to address this vastly unmet percutaneous structural heart market by delivering…
CHRISTOPHER EDWARDS · EMORY UNIVERSITY · 2024 · $48,974 — Abstract The humoral immune system relies on the rich diversity of the antibody binding repertoire to generate targeted responses to the vast array of antigens one may encounter, and much work has been done to characterize the factors generating this diversity. However, allelic variation at the high…
ELLIOTT S FISHER · DARTMOUTH COLLEGE · 2024 · $806,395 — ABSTRACT Disparities in health within the U.S. are pervasive and, for some populations, widening. High-quality primary care plays an important role in the prevention, diagnosis and management of the many chronic health conditions that contribute to health disparities among older adults. Primary care…
Ashley Comiford · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · 2024 · $175,285 — Project Summary/Abstract American Indian/Alaska Native (AI/AN) populations were disproportionately affected by the COVID-19 pandemic compared to other racial/ethnic populations. AI/AN individuals experience a higher prevalence of chronic diseases that increase risk of COVID-19 complications includin…
David S. Bradley · UNIVERSITY OF NORTH DAKOTA · 2024 · $1,998,812 — Summary This COBRE Phase 2 application proposes continued support of the UND Center for Excellence in Host- Pathogen interaction (HPI). The long-term goal of this center is to develop a deeper understanding of host responses to viral, bacterial and parasitic insults leading to acute and chronic infl…
Edward M. Schwarz · UNIVERSITY OF ROCHESTER · 2024 · $1,322,427 — Abstract Bone infection caused by Staphylococcus aureus remains the bane of orthopaedic surgery, as diagnostics, prophylactics and treatments have significant shortcomings that result in catastrophic outcomes for patients, and crippling healthcare costs. Although the incidence of infection following…
VESNA D GAROVIC · MAYO CLINIC ROCHESTER · 2024 · $200,633 — OVERALL: Project Summary/Abstract Mayo Clinic is one of the largest not-for-profit, academic health systems, top-ranked for quality more often than any other health care organization. It has integrated operations in 5 U.S. states, and more than 1 million people came to Mayo Clinic for care last year…
Jennifer Feder Bobb · FRED HUTCHINSON CANCER CENTER · 2024 · $132,840 — Project Summary/Abstract In biomedical research, the need for a diverse pool of researchers in statistics and data science has never been greater. Yet, the requisite academic pipeline for training such a workforce remains inadequate. Minority students admitted to statistics or biostatistics graduate…
Nathalie Hill-Kapturczak · WASHINGTON STATE UNIVERSITY · 2024 · $691,670 — PROJECT SUMMARY/ABSTRACT In 2020, 28.3 million Americans experienced an alcohol use disorder (AUD); yet only 25% of these people received treatment. During the pandemic, 60% of patients with a substance use disorder reported receiving telehealth-based care for their addiction. The pivot to telehealt…
Gary S Gilkeson · MEDICAL UNIVERSITY OF SOUTH CAROLINA · 2024 · $1,225,013 — Abstract Cellular therapies for the treatment of autoimmune diseases offers a novel treatment option with possible increased efficacy and decreased toxicity. We are performing the first multi-center double blind placebo controlled dose escalation trial of mesenchymal stromal cells (MSCs) for standar…