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9873 documents

NIAID VIROLOGY QUALITY ASSURANCE (VQA) COVID-19

NIH Pandemic-Era Grants · Pandemic Era Grants / 2020

THOMAS DENNY · DUKE UNIVERSITY · 2020 · $668,265 — The purpose of the NIAID Virology Quality Assurance (VQA) program is to provide a comprehensive quality assessment program for virologic assays for HIV, and other viral pathogens, performed on samples from subjects enrolled in NIAID-sponsored multisite clinical studies. The VQA program ensures the v…

COVID Supplement - COMPONENT A OF THE COLLABORATIVE INFLUENZA VACCINE INNOVATION CENTERS (CIVICS) PROGRAM TO DESIGN AND EVALUATE INNOVATIVE INFLUENZA VACCINE APPROACHES,

NIH Pandemic-Era Grants · Pandemic Era Grants / 2020

TED ROSS · UNIVERSITY OF GEORGIA · 2020 · $969,746 — The objective of this contract program is to support improvements in the immunogenicity and durability of seasonal influenza vaccines, SARS-COV-2 vaccines and the development of innovative influenza vaccine approaches that provide robust, durable, broadly protective mucosal and systemic anti-influen…

Predictors of Influenza-Associated Absenteeism and Impact of Vaccination in a Cohort of Guatemalan Agricultural Workers

NIH Pandemic-Era Grants · Pandemic Era Grants / 2020

Daniel Olson · UNIVERSITY OF COLORADO DENVER · 2020 · $49,756 — PROJECT SUMMARY/ABSTRACT This is an Administrative Supplement Application to carry out SARS-CoV-2 PCR testing in an existing NIAID- funded study (1K23AI143967) evaluating the clinical and economic impacts of influenza in Guatemalan agricultural workers. The Parent Study includes the enrollment of an…

The role of precarious work in the production of health disparities in older ages

NIH Pandemic-Era Grants · Pandemic Era Grants / 2020

Anjum Hajat · UNIVERSITY OF WASHINGTON · 2020 · $234,766 — ABSTRACT The COVID-19 pandemic has highlighted - and exacerbated - the pervasive race/ethnic and social class based health inequities in the US today. Our essential but precarious food provision, service, and delivery workers are at increased risk of exposure to SARS-COV-2 and related health consequ…

UAW NIEHS Worker Training Program Coronavirus and Infectious Disease Response Training (Admin Supp Clinical Trial Not Allowed)

NIH Pandemic-Era Grants · Pandemic Era Grants / 2020

ANDY COMAI · INTERNATIONAL UNION, UAW OF AMERICA, AFL-CIO · 2020 · $199,584 — Project Summary/Abstract The International Union, UAW and its partners propose to conduct training to prevent and reduce exposure to SARS-CoV-2 among healthcare workers, emergency first responders, manufacturing workers, and members of underserved Hispanic/Latino communities. The paramount goal of …

Facilitating Sustainment Through Implementation Feedback: The SIC Coaching Model

NIH Pandemic-Era Grants · Pandemic Era Grants / 2020

Lisa Saldana · OREGON SOCIAL LEARNING CENTER, INC. · 2020 · $150,092 — PARENT GRANT PROJECT SUMMARY/ABSTRACT This proposal, in response to PAR-16-455, aims to test the impact of an empirically derived implementation strategy—under real-world conditions and across multiple child service systems—on successful adoption and sustainment of two evidence-based programs that …

Predictors of Recovery and the App-Facilitated Tele-Rehabilitation (AFTER) Program for COVID Survivors

NIH Pandemic-Era Grants · Pandemic Era Grants / 2020

Kristine Mace Erlandson · UNIVERSITY OF COLORADO DENVER · 2020 · $523,492 — PROJECT SUMMARY/ABSTRACT Older adults and adults with comorbidities or disability are at highest risk for morbidity and mortality from COVID-19, although many healthy middle-aged adults without underlying risk factors also experience severe disease, likely driven by a profound and exaggerated inflam…

Recombinant BCG-based SARS-CoV-2 vaccine

NIH Pandemic-Era Grants · Pandemic Era Grants / 2020

Mary Jackson · COLORADO STATE UNIVERSITY · 2020 · $411,968 — Summary The scale of the humanitarian and economic impact of the COVID-19 pandemic places a high priority on the development of prophylactic and therapeutic countermeasures to better control SARS-CoV-2 infections. Among the priorities listed in the NIAID Strategic Plan for COVID-19 research is the n…

A Lung-chip microphysiological system to model SARS-CoV-2 infection and test novel therapeutics

NIH Pandemic-Era Grants · Pandemic Era Grants / 2020

CLIVE Niels SVENDSEN · CEDARS-SINAI MEDICAL CENTER · 2020 · $1,163,750 — Project Abstract SARS-CoV-2 novel coronavirus has caused a pandemic, presenting us with an urgent need to develop new models to study the pathophysiology of infection and test innovative therapeutics to combat disease. This proposal aims to use chip-based microphysiological systems to establish a mo…

A Multipronged Interrogation of Large-Scale Omics Data to Reveal COVID-19 Pathways

NIH Pandemic-Era Grants · Pandemic Era Grants / 2020

Sharlee Climer · WASHINGTON UNIVERSITY · 2020 · $650,002 — The COVID-19 global pandemic has led to more than 470,000 deaths. This disease is especially perilous for the elderly - 80% of deaths in the US have been individuals over the age of 65, and the social isolation created by lockdowns have increased risks of serious physical and mental health issues. …

High-throughput CRISPR-based Diagnostic Assay for Coronaviruses and Other Respiratory Diseases

NIH Pandemic-Era Grants · Pandemic Era Grants / 2020

Bruce W. BIRREN · BROAD INSTITUTE, INC. · 2020 · $349,995 — This proposal is intended to develop novel clinical diagnostics for, and increase our understanding of, the diversity, evolution, and spread of the newly emerged SARS-related coronavirus 2 (SARS-CoV-2) and other respiratory disease-causing pathogens in the United States. Coronavirus Disease 2019 (CO…

UCSF COVID-19 Immunophenotyping Clinical Study and Core Laboratories

NIH Pandemic-Era Grants · Pandemic Era Grants / 2020

David J Erle · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2020 · $5,742,559 — PROJECT SUMMARY/ABSTRACT COVID-19, the pandemic illness caused by the novel virus SARS-CoV-2, is a serious respiratory illness that has high infectivity and a mortality rate that varies from <1% to up to 20% depending on underlying risk factors. Indeed, disease severity varies markedly based on reco…

IMmunoPhenotyping Assessment of a Covid-19 Cohort (IMPACC): Clinical Site

NIH Pandemic-Era Grants · Pandemic Era Grants / 2020

OFER LEVY · BOSTON CHILDREN'S HOSPITAL · 2020 · $184,957 — PROJECT SUMMARY: From a cluster of respiratory illnesses in Wuhan, China, to a worldwide pandemic, the world has learned of a novel coronavirus (SARS-CoV-2) but little is known about the pathogenesis that leads to the disease termed “COVID”. Patients with SARS-CoV-2 infection range from asymptomatic…

Omics analysis of HIV during synthetic opioid exposure

NIH Pandemic-Era Grants · Pandemic Era Grants / 2020

JASON T BLACKARD · UNIVERSITY OF CINCINNATI · 2020 · $150,215 — Abstract In December 2019, an outbreak of pneumonia of unknown cause occurred in Wuhan, China, and the causative agent was identified as a novel coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Additionally, the US is in the midst of a major opioid epidemic largely att…

Cancer Center Support Grant (CCSG)

NIH Pandemic-Era Grants · Pandemic Era Grants / 2020

GARTH POWIS · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · 2020 · $487,500 — The scientific community has mobilized around the novel coronavirus, SARS-CoV-2 which causes the pneumonia like disease named COVID-19. This virus has impacted over 210 countries and territories and almost 1.5 million people worldwide since December 2019, according to the Coronavirus Disease (COVID1…

Phase IbTrial of Rintatolimod and IFNa Regimen in Cancer Patients with Mild or Moderate COVID-19 infection

NIH Pandemic-Era Grants · Pandemic Era Grants / 2020

CANDACE S JOHNSON · ROSWELL PARK CANCER INSTITUTE CORP · 2020 · $420,500 — Following infection with the novel coronavirus SARS-CoV-, immunocompromised and older individuals are at higher risk of severe illness and fatality. Patients with cancer exhibit multiple factors associated with elevated morbidity and mortality from COVID-19, including older age, pre-existing cardiac…

Predicting medical consequences of novel fentanyl analog overdose using the Toxicology Investigators Consortium (TOXIC)

NIH Pandemic-Era Grants · Pandemic Era Grants / 2020

Alex Francis Manini · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2020 · $149,395 — ABSTRACT AND PROJECT SUMMARY The purpose of this R01 proposal is to deepen our knowledge of the primary cause of drug overdose deaths in the U.S. today: novel psychoactive synthetic opioids, the majority of which are fentanyl analogues. Using a multicenter network, patients who present to emergency …

MIS-C Program: Data Coordinating Center for the Pediatric Heart Network MIS-C Program

NIH Pandemic-Era Grants · Pandemic Era Grants / 2020

Julie Elaine Miller · NEW ENGLAND RESEARCH INSTITUTES, INC. · 2020 · $4,327,649 — PROJECT SUMMARY/ABSTRACT To address the knowledge gap discussed previously, NIH is initiating a national research program focused on pediatric SARS-CoV-2, COVID-19 and MIS-C. This goal of the program is to gain comprehensive understanding of phenotype, natural history, outcomes, and pathobiology of …

Interferon hyperactivity, COVID19, and Down syndrome

NIH Pandemic-Era Grants · Pandemic Era Grants / 2020

Joaquin M. Espinosa · UNIVERSITY OF COLORADO DENVER · 2020 · $619,607 — PROJECT SUMMARY. This is an application for an Urgent Competitive Revision to our Transformative R01 award funded by the NIH INCLUDE Project and NIAID titled ‘Understanding Down Syndrome as an Interferonopathy’. The central hypothesis of the parent award is that hyperactivation of interferon (IFN) s…