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9873 documents

Administrative Core

NIH Pandemic-Era Grants · Pandemic Era Grants / 2022

David S Perlin · HACKENSACK UNIVERSITY MEDICAL CENTER · 2022 · $7,558,755 — The MAVDA Administrative Core (MAC) will be established as an integrated, priority-setting consortium involving the Program Directors (PDs), a Business Director (BD), an internal MAVDA Leadership Team (MLT), and a Scientific Advisory Board (SAB) with programmatic involvement from NIAID to enhance po…

Core 06: Biomedical Informatics Core

NIH Pandemic-Era Grants · Pandemic Era Grants / 2022

Lucio Miele · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · 2022 · $276,877 — Project Summary: Biomedical Informatics Core The overall goal of the Biomedical Informatics (BMI) Core of the Louisiana Clinical and Translational Science Center (LA CaTS) is to build on our accomplishments and continue to develop and deploy “state of the art” informatics services to LA CaTS inve…

Addressing community-level influences of HIV and COVID-19 disparities among people with HIV

NIH Pandemic-Era Grants · Pandemic Era Grants / 2022

Diana Montserrat Sheehan · FLORIDA INTERNATIONAL UNIVERSITY · 2022 · $354,222 — FIU-RCMI Research Project #3 Abstract The twin pandemics of human immunodeficiency virus (HIV) and COVID-19 share uncanny similarities with respect to racial/ethnic and socioeconomic disparities in both incidence and mortality. Structural strategies for HIV and COVID-19 outcomes could augment curren…

Administrative Core

NIH Pandemic-Era Grants · Pandemic Era Grants / 2022

Alan Tackett · ARKANSAS CHILDREN'S HOSPITAL RES INST · 2022 · $770,000 — PROJECT SUMMARY The Administrative Core will provide operational oversight for the Center for Translational Pediatric Research (CTPR) at the Arkansas Children’s Research Institute (ACRI) during COBRE Phase II. The Center Director, Dr. Alan Tackett, will lead the Administrative Core both in the scien…

Core B: Organoid Core

NIH Pandemic-Era Grants · Pandemic Era Grants / 2022

CALVIN J KUO · STANFORD UNIVERSITY · 2022 · $529,054 — PROJECT SUMMARY (Core B: Organoid Core) Infectious disease research is substantially hampered by lack of experimental models necessary to study interactions between pathogens and target tissues; a glaring deficiency amplified by the recent COVID-19 pandemic. The recent advent of 3D organoid methods …

Administrative Core

NIH Pandemic-Era Grants · Pandemic Era Grants / 2022

JOHN P. KIRWAN · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · 2022 · $123,969 — Project Summary: Administrative Core The LA CaTS Center Administrative Core has been set up to promote, support, and continually evolve the governance and administrative structure of the Center, to effectively facilitate the necessary leadership, tools and processes required to integrate and align …

CENTERSFOR RESEARCH ON STRUCTURAL BIOLOGY OF INFECTIOUS DISEASES

NIH Pandemic-Era Grants · Pandemic Era Grants / 2022

KARLA SATCHELL · NORTHWESTERN UNIVERSITY AT CHICAGO · 2022 · $238,466 — To apply state-of-the-art, high-throughput structural biology technologies to experimentally characterize the three-dimensional atomic structure of targeted proteins on the NIAID Category A-C priority pathogens list and organisms causing emerging and re-emerging infectious diseases. This program als…

NIAID-VRC- Rapid Manufacturing Response

NIH Pandemic-Era Grants · Pandemic Era Grants / 2022

DAVID LINDSAY · LEIDOS BIOMEDICAL RESEARCH, INC. · 2022 · $9,822,408 — The Vaccine Research Center (VRC) mission and scope includes rapidly moving clinical candidates from the research bench through development and GMP manufacturing to the clinic. The VRC is exploring a wide range of initiatives, including but not limited to new technologies which would decrease the ti…

NIAID DCR OPERATIONAL TASK ORDERCOVID FUNDING SUPPORTS THE NIAID DCR COVID WEBSITE AND THE VARIANT TESTING SAVE PROGRAM FOR VARIANT TESTING.

NIH Pandemic-Era Grants · Pandemic Era Grants / 2022

BARRY GAUSE · LEIDOS BIOMEDICAL RESEARCH, INC. · 2022 · $1,200,000 — COVID SARS-CoV-2 Assessment Viral Evolution (SAVE) variant testing provides support for analysis of SARS-CoV-2 genome sequences from specimens collected in COVID-19 therapeutic and observational trials for genetic variants that could impact diagnostics, therapeutics, vaccine efficacy, and disease se…

Digital Health Technologies Data Hub

NIH Pandemic-Era Grants · Pandemic Era Grants / 2022

Tony Dickherber · NATIONAL CANCER INSTITUTE · 2022 · $2,129,500 — In May 2020, in response to the rapidly expanding pandemic caused by the SARS-CoV-2 virus, the National Cancer Institute (NCI) and the National Institute of Biomedical Imaging and Bioengineering (NIBIB) launched a program called Digital Health Solutions for COVID-19. The goal of this initiative was …

Addition of Social Needs to a Telephone-Based Developmental Care Coordination Randomized Controlled Trial in the Era of COVID

NIH Pandemic-Era Grants · Pandemic Era Grants / 2022

PAUL J CHUNG · KAISER FOUNDATION RESEARCH INSTITUTE · 2022 · $132,460 — PROJECT SUMMARY/ ABSTRACT Although universal early childhood developmental screening is recommended by the American Academy of Pediatrics, ample evidence suggests that child health providers are not meeting those recommendations, and many early developmental delays are being missed. Additional evide…

High-Throughput Dried Blood Spot (HT-DBS) Technologies in SARS COV-2 Serology and Vaccinology

NIH Pandemic-Era Grants · Pandemic Era Grants / 2022

Nicholas J. Mantis · WADSWORTH CENTER · 2022 · $592,301 — Project Summary As the COVID-19 pandemic continues to spread across the United States it is imperative that we implement technologies to screen large swaths of the population for the presence of antibodies to SARS-CoV-2. Serological surveillance not only affords a measure of virus exposure within a …

Preclinical development of an immunomodulatory agent capable of mitigating SARS-CoV-2 virus related hypercytokinemia

NIH Pandemic-Era Grants · Pandemic Era Grants / 2022

JODI K CRAIGO · CYTOAGENTS, INC. · 2022 · $1,000,000 — Abstract CytoAgents is developing GP1681 (beraprost-314d) to regulate the uncontrolled inflammatory response that can result from viral infections. This inflammatory response is associated with increased disease severity, acute lung injury (ALI), acute respiratory distress syndrome (ARDS), and death…

Regional Biocontainment Laboratory (RBL) Upgrade for Colorado State University (CSU)

NIH Pandemic-Era Grants · Pandemic Era Grants / 2022

Karen Marie Dobos · COLORADO STATE UNIVERSITY · 2022 · $3,193,195 — Project Summary / Abstract The funding and implementation of this supplement is essential to maintain uninterrupted research and scholarly activity in CSU’s Rocky Mountain Regional Biocontainment Laboratory (RMRBL). Research activities that occur at the RMRBL directly address the RBLs’ missions to r…

The Role of Obesity on Alphavirus Disease Severity

NIH Pandemic-Era Grants · Pandemic Era Grants / 2022

James D Weger · VIRGINIA POLYTECHNIC INST AND ST UNIV · 2022 · $190,284 — Project Summary/Abstract Chikungunya virus (CHIKV), an NIAID category B pathogen, causes a debilitating arthritic disease that can last for years. A massive outbreak of CHIKV occurred throughout the Americas in 2013, with an estimated 39.9 million people infected. Closely related viruses include Ro…

Novel diagnostic tools and animal model system for study human/animal interface of COVID-19

NIH Pandemic-Era Grants · Pandemic Era Grants / 2022

Diego G Diel · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · 2022 · $778,213 — The ongoing pandemic of COVID-19 is designated by World Health Organization (WHO) as a Public Health Emergency of International Concern. Similarities among ACE2 receptors predict that there are several animals could function as reservoirs for the virus. Recent studies by us and others identified fel…

Pandemic Preparedness: Biocontainment Facility Upgrade and Integration at UTMB/Galveston National Laboratory

NIH Pandemic-Era Grants · Pandemic Era Grants / 2022

Gary Kobinger · UNIVERSITY OF TEXAS MED BR GALVESTON · 2022 · $7,131,815 — PROJECT SUMMARY/ABSTRACT Toward maintaining and improving pandemic preparedness, we propose value-added facility upgrades that better integrate the high-containment communities at the University of Texas Medical Branch (UTMB), Galveston. UTMB laboratories integrate operations through joint-facility …

BSL3 Enhancements for RNA Virus Pandemic Preparedness

NIH Pandemic-Era Grants · Pandemic Era Grants / 2022

Hardy Kornfeld · UNIV OF MASSACHUSETTS MED SCH WORCESTER · 2022 · $3,994,219 — Program Summary/Abstract The University of Massachusetts Chan Medical School (UMass Chan) seeks NIH G20 funding to repair, renovate, and modernize the existing Biosafety Level 3 (BSL3) and Animal BSL3 (ABSL3) facilities to enhance current research on RNA viruses of pandemic potential. As an internat…

Impact of COVID-19 on disinfectant exposure and associated health effects.

NIH Pandemic-Era Grants · Pandemic Era Grants / 2022

Soo-Jeong Lee · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2022 · $201,875 — PROJECT SUMMARY/ABSTRACT Disinfectants are widely used in various products and in various settings to prevent infection and transmission of harmful pathogens. Disinfectants, however, contain hazardous chemicals and are known to cause irritation or allergic symptoms in eyes, skin, respiratory and ner…

Center for Translational Pediatric Research (CTPR): Enhancing SARS-CoV-2 Sequencing Efforts for Variants in the State of Arkansas

NIH Pandemic-Era Grants · Pandemic Era Grants / 2022

Alan Tackett · ARKANSAS CHILDREN'S HOSPITAL RES INST · 2022 · $770,000 — Summary In July of 2017, we launched Phase I of the COBRE Center for Translational Pediatric Research at Arkansas Children’s Research Institute in Little Rock, Arkansas. The mission of the center is to use proteogenomic approaches to identify epigenomic mechanisms and therapeutic targets in disease…