Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Lawrence Anthony David · DUKE UNIVERSITY · 2024 · $238,943 — ABSTRACT: Urine and stool output tracking is essential for hospital treatment of diseases related to the heart, lungs, and blood. For patients who can walk, output monitoring currently involves patients using plastic waste collection hats. The manual nature of patient and nurse handling of collectio…
Scott C Weaver · UNIVERSITY OF TEXAS MED BR GALVESTON · 2024 · $987,497 — ABSTRACT As underscored by pandemic COVID-19, Zika, yellow fever and chikungunya viruses, new and emerging viruses represent increasing threats to human health, yet their mechanisms of emergence remain poorly understood, and effective interventions are not available for most. Research on their patho…
MEREDITH C. B. ADAMS · UNIVERSITY OF ROCHESTER · 2024 · $710,065 — Opioid use disorder (OUD) is a national crisis that affects public health and economic stability. Recent years have witnessed the highest overdose death toll since 2017, with a 50% increase in overdose mortality rate and limited understanding of underlying contributing factors. Economic disruption f…
Jeffrey Andrew Sparks · BRIGHAM AND WOMEN'S HOSPITAL · 2024 · $716,336 — PROJECT SUMMARY The 5 million Americans living with systemic autoimmune rheumatic diseases (SARDs), such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), are at increased risk of poor COVID-19 outcomes. SARO treatment with immunomodulators may lead to blunted and dysregulated imm…
Anthony Griffiths · UNIVERSITY OF MISSOURI-COLUMBIA · 2024 · $2,375,210 — Overall Project Summary Resources and Workforce Development for Research on NIH/NIAID High Priority Pathogens at the University of Missouri Regional Biocontainment Laboratory The University of Missouri Regional Biocontainment Laboratory (RBL) was commissioned in 2009 as an $18M, 12,377 NSF BSL-3/ABS…
L Lee HAMM · TULANE UNIVERSITY OF LOUISIANA · 2024 · $499,999 — Project Summary – Overall The Tulane National Primate Research Center (TNPRC) is affiliated with Tulane University of Louisiana and was dedicated in 1964. The Center is part of Tulane University Health Sciences along with the School of Medicine, the School of Public Health and Tropical Medicine, and…
Jin Liu · WASHINGTON STATE UNIVERSITY · 2024 · $284,953 — Virus infections remain major threats to human health worldwide as demonstrated by COVID-19 pandemic caused by SARS-CoV-2 and its variants. All enveloped viruses must fuse with host membranes to initiate the infection process. Membrane fusion is a critical, but poorly understood biological process…
ALBERTO ASCHERIO · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · 2024 · $638,783 — PROJECT SUMMARY The highest priority recommended by NINDS for clinical Parkinson’s research is to define “the features and natural history of prodromal Parkinson disease (PPD), including the events that underlie phenoconversion to clinically manifest PD, and biomarkers or other determinants of prodr…
DEAN R MADDEN · DARTMOUTH COLLEGE · 2024 · $2,460,000 — The Dartmouth Institute for Biomolecular Targeting (bioMT) infuses mechanistic investigations with a sophisticated awareness of disease pathology and therapeutic need, enhancing the quality of even the most fundamental research. At the same time, it helps orient mechanistic investigations towards lo…
George Parsons Langan · UNIVERSITY OF CHICAGO · 2024 · $2,464,978 — PROJECT ABSTRACT (OVERALL) Our nation’s ability to detect, prevent and counter bioterrorism and emerging infectious diseases depends on technologies that are generated through biomedical research on disease-causing microbes and understanding human immune responses to infection. Following bioterroris…
Susan Buchanan · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · 2024 · $787 — CTCF and chromatin structure. Histone proteins package and condense genomic DNA into chromatin within the cell nucleus. Proteins such as the CCCTC binding factor (CTCF) help direct chromatin higher-order organization through passive and active mechanisms by imposing topological constraints, mediat…
Paule Joseph · NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM · 2024 · $80,796 — We wrote our clinical protocol for submission to IRB soon. However, through collaborations with other investigators both intramural and extramural we have published a number of manuscripts regarding this topic. The multimodal impact of COVID-19 and the lack of perceived nasal obstruction suggest t…
John O'Shea · NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES · 2024 · $282,598 — Cytokines comprise a large family of secreted proteins that regulate cell growth and differentiation of many types of cells. These factors are especially important in regulating immune and inflammatory responses, and regulating lymphoid development and differentiation. Not surprisingly, cytokines ar…
Richard Davey · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2024 · $4,224,059 — Novel means first to better characterize and then to treat infection with major respiratory pathogens using existing or newly developed strategies are a primary focus of this important project within the Clinical Research Section. In this regard, our Section has undertaken clinical research efforts …
Helen Chun-Hui Su · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2024 · $628,084 — These studies have been organized as part of a broader effort among multiple principal investigators in the Intramural Research Programs of NIAID and other institutes, as well as a research collaborative agreement with investigators at the American Genome Center/Uniformed Services University of the …
Helen Chun-Hui Su · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2024 · $144,905 — The single-stranded RNA virus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has proven to be easily transmissible in humans. Infected individuals present with a range of COVID-19 disease-associated characteristics: on the low end of the spectrum patients are asymptomatic or display mi…
Hans Ackerman · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2024 · $2,194,965 — Impaired nitric oxide synthase-dependent vasodilation is a common hallmark of infectious, inherited, and metabolic vascular diseases ranging from malaria to atherosclerosis. Efforts to restore nitric oxide (NO) signaling have been limited by an incomplete understanding of NO regulation in human arte…
Janet Hall · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · 2024 · $5,483,797 — The NIEHS Clinical Research Branch has continued to expand its scope of support for clinical and translational studies. The NIEHS Clinical Research Unit (CRU) has recorded over 11,000 patient encounters with over 95% patient satisfaction. Additional staff have been hired to support CRU functions. …
Alan Koretsky · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · 2024 · $145,123 — As originally planned when this project first started, it has now transitioned to be fully performed at the Uniformed Services University of the Health Sciences (USHSU). David Brody is the PI of the project at USHSU and he has been successful at getting funding independent of NINDS intramural resea…
Yan Li · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · 2024 · $1,011,974 — PCF is equipped with a Thermo Fisher Lumos mass spectrometer with an nanoflow Ultimate 3000 HPLC, a Thermo Fisher Ascend mass spectrometer with a Vanquish NEO HPLC, and an Agilent 6545XT Advance Bio LC/Q-TOF System. PCF seeks to provide high quality proteomics services on intact Protein molecular …