Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Bahram Razani · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2024 · $189,000 — PROJECT SUMMARY: The relationship between psoriatic skin and joint disease remains enigmatic. A subset of patients with psoriasis develop arthritis, early diagnosis of which is challenging. Additionally, therapies for skin disease are less successful at treating arthritis. A20 (Tnfaip3) is a broadly…
Gavin John Churchyard · AURUM INSTITUTE NPC · 2024 · $1,408,715 — PROJECT SUMMARY Southern and East Africa is home to 54% of the world’s people living with HIV, with Southern Africa remaining as the epicenter of the global HIV pandemic. The proposed Aurum South and East African Clinical Trials Unit (ASEA CTU) brings together a unique South–South partnership led by…
Bethany B. Moore · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2024 · $839,331 — The overarching theme for our research program over the past 20 years has been to better understand the etiology and pathogenesis of lung injury, repair and remodeling, with a particular interest in how the immune response shapes pathologic and homeostatic processes in the lung. Our laboratory has c…
Markus Schober · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · 2024 · $437,810 — SUMMARY SOX2 is a cell fate–determining transcription factor that is expressed in ~70% of cutaneous and head and neck squamous cell carcinomas (SCCs) in patients. SOX2 is highly enriched in stem cell–like tumor-propagating cells (TPCs), which are located within the basal SCC layer where they can sel…
Linda G Kahn · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · 2024 · $248,784 — PROJECT SUMMARY/ABSTRACT In the United States, increasing numbers of women are experiencing pregnancy complications such as preeclampsia, eclampsia, and gestational hypertension that can put their own and their children’s immediate and long-term health at risk. In particular, these hypertensive diso…
JOSHUA M KAPLAN · MASSACHUSETTS GENERAL HOSPITAL · 2024 · $568,605 — Analysis of calcium signaling in C. elegans The goal of this project is to analyze mechanisms controlling signaling by voltage-activated calcium (CaV) channels. In neurons and muscles, brief cytoplasmic calcium transients efficiently and rapidly activate downstream effectors, often on millisecond t…
Aimee Shen · TUFTS UNIVERSITY BOSTON · 2024 · $362,992 — SUMMARY The bacterial pathogen, Clostridioides difficile, has been designated an urgent threat to the US healthcare system by the Centers for Disease Control. In order for C. difficile to initiate infection, its infectious spore form must germinate in the gut of susceptible individuals. Since spore …
David W Haas · VANDERBILT UNIVERSITY MEDICAL CENTER · 2024 · $2,649,501 — PROJECT SUMMARY/ABSTRACT The HIV pandemic is one of the greatest ongoing threats to health and development, over 35 years past its recognition. The NIAID-funded Clinical Trials Networks have played critical roles in the coordinated response to key research questions in the HIV/AIDS field, which will…
Margaret Juliana McElrath · FRED HUTCHINSON CANCER CENTER · 2024 · $28,707,507 — The overall goal of the Laboratory Center (LC) is to provide the leadership, structure, oversight and execution of high-quality, state-of-the-art laboratory-based research studies on behalf of the HIV Vaccine Trials Network (HVTN) that will accelerate the development of a safe and efficacious HIV va…
Orin Bloch · UNIVERSITY OF CALIFORNIA AT DAVIS · 2024 · $105,412 — PROJECT SUMMARY/ABSTRACT The outcome of brain tumor surgery is critically dependent on the neurosurgeon's ability to distinguish between abnormal and normal tissue in real-time. Our goal is to enhance this discrimination by using label-free Fluorescence Lifetime Imaging (FLIm) to detect tissue bioch…
Catherine J Chu · MASSACHUSETTS GENERAL HOSPITAL · 2024 · $662,002 — Project Summary Epilepsy is the world’s most common, serious brain disorder, affecting nearly 50 million people worldwide. For one-third of patients, seizures remain poorly controlled despite maximal medical management. In these patients, seizures often arise from a localized brain region, and neuro…
DALE L BOGER · SCRIPPS RESEARCH INSTITUTE, THE · 2024 · $407,250 — Complementary to efforts supported by this grant that led to the characterization of the first signaling fatty acid primary amide, its hydrolysis and signaling termination by and discovery of fatty acid amide hydrolase (FAAH), and the validation of FAAH as a therapeutic target modulating the activit…
Mariana Kruger · UNIVERSITY OF KWAZULU-NATAL · 2024 · $243,694 — PROJECT SUMMARY: The SARETI research ethics doctoral leadership program will extend the achievements of the SARETI Masters run by our intensively multidisciplinary faculty since 2002. The PhD program will offer comprehensive, multidisciplinary advanced doctoral and leadership training in research e…
LISHAM ASHRAFIOUN · VETERANS AFFAIRS, UNITED STATES DEPARTMENT OF · 2024 — Loneliness—a subjective emotional state characterized by the perception of social isolation—is a psychosocial stressor that is associated with increased mortality and chronic pain. Individuals who have chronic pain and report loneliness experience greater pain-related interference in activities, dep…
David E Kang · CASE WESTERN RESERVE UNIVERSITY · 2024 · $512,136 — Project Summary Accumulating evidence indicates that the ability to mount an effective Nrf2-mediated gene expression response to oxidative stress declines during the aging process. In particular, nuclear but not cytoplasmic Nrf2 is depleted in neurons of AD patients. In animal models, loss of Nrf2 s…
Aimin Chen · UNIVERSITY OF PENNSYLVANIA · 2024 · $1,128,534 — Philadelphia Regional Center for Children's Environmental Health (PRCCEH) is a new children's center which will provide the infrastructure to integrate CEH research expertise at University of Pennsylvania (Penn) Perelman School of Medicine (PSOM), Children's Hospital of Philadelphia (CHOP), Drexel U…
Hans C Oettgen · BOSTON CHILDREN'S HOSPITAL · 2024 · $598,688 — While food allergy has emerged as a major health issue, treatment options are quite limited. There is an urgent need to identify the specific environmental and endogenous factors that prime and then sustain allergic responses to foods so that new mechanism-based therapies can be developed. We have f…
Pedro R. Lowenstein · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2024 · $489,027 — Abstract Malignant gliomas continue to be the most aggressive and lethal of all brain tumors. In spite of improvements in surgery, radiotherapy, and chemotherapy, median survival remains ~18-24 months. Gliomas are infiltrative tumors that invade the surrounding normal brain tissue making total surgi…
Bernadett Papp · UNIVERSITY OF FLORIDA · 2024 · $354,944 — Abstract Kaposi’s sarcoma-associated herpesvirus (KSHV) is large DNA virus, which is the etiological agent of several AIDS-related malignancies such as Kaposi’s sarcoma, primary effusion lymphoma, and aggressive forms of multicentric Castleman’s disease. Lytic replication of KSHV is critical for bot…
Sharla Annette Smith · UNIVERSITY OF KANSAS MEDICAL CENTER · 2024 · $140,413 — Project Summary/Abstract My long-term career goal is to become an independent leading scholar (with R01 funding) drawing on concepts and methods to improve prenatal care and maternal outcomes among Black women who are three times more likely than White women to die from preeclampsia, specifically ea…