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9873 documents

Center for Healthcare Organization and Implementation Research

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

BARBARA G. BOKHOUR · VA BOSTON HEALTH CARE SYSTEM · 2024 — Created in 2013 from the merger of two successful Boston-area HSR&D Centers of Excellence, CHOIR – the Center for Healthcare Organization and Implementation Research – now has the scientists, the environment, and the resources to respond and contribute to the challenges that Veterans' healthcare wil…

Plan to Enhance Diversity

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Antwione Maurice Haywood · INDIANA UNIVERSITY INDIANAPOLIS · 2024 · $283,243 — ABSTRACT, Plan to Enhance Diversity (PED) According to a survey by the Association of American Cancer Institutes and reported in The Cancer Letter, the lack of diversity in senior leadership positions at NCI-designated cancer centers is a significant issue. Interestingly, cancer centers led by women…

Single Cell Core

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Peter Alan Sims · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2024 · $359,953 — SINGLE CELL CORE: PROJECT SUMMARY The Single Cell Core will provide state-of-the-art experimental technology for single-cell multi-omic profiling. Two major limitations of conventional scRNA-seq for immunophenotyping include the lack of correlation between mRNA levels and surface protein expression …

Human Airway Biomimetics for RSV and Other Respiratory Viruses

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Pedro A Piedra · BAYLOR COLLEGE OF MEDICINE · 2024 · $344,608 — PROJECT SUMMARY – Project 2 Respiratory syncytial virus (RSV) is a major global respiratory pathogen. The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) pandemic has resulted in an unprecedented crisis. Respiratory virus infections are often accompanied by gastrointestinal (GI) symptom…

Scientific Project 3: Covid Immune response to SARS-CoV-2 natural infection followed by vaccination

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Gregory Lee Szeto · SEATTLE CHILDREN'S HOSPITAL · 2024 · $125,294 — HIPC3 Scientific Project 3: Immune response to SARS-CoV-2 natural infection followed by vaccination Abstract This project will characterize the innate and adaptive immune response to SARS-CoV-2 natural infection in the setting of mild disease and follow-on vaccination. We will define signatures corr…

Regulation of B cell Responses in SLE and Other Autoimmune Diseases

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Ignacio E. Sanz · EMORY UNIVERSITY · 2024 · $234,750 — Systemic Lupus Erythematosus (SLE) is a systemic autoimmune disease generated by abnormal B cell function that induces pathogenic autoantibodies. Our lab has previously defined multiple B cell abnormalities in SLE including the recent definition of an extrafollicular (EF) pathway responsible for the…

Clinical Resources Core

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Robert Hal Scofield · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · 2024 · $636,668 — Although some improvement has been made since the Oklahoma Shared Clinical and Translational Resources (OSCTR) initiation, Oklahoma remains consistently in or near the bottom 10% of states for the overall health of its population. Oklahoma’s residents disproportionately suffer from chronic health …

Role of CASP-11 in SARS-CoV-2-induced lung pathologies and long-term immune protection

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Prosper N Boyaka · OHIO STATE UNIVERSITY · 2024 · $658,785 — PROJECT 1 - ABSTRACT The rapid development of SARS-CoV-2 vaccines has helped ease most of the restrictions in place during the height of the pandemic to limit transmission of the virus. Unfortunately, the adaptive immunity (i.e., antibody and T cell responses) induced by current vaccines declines ra…

Rapid Response and Pilot Research Core

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Judith A Wilde · GEORGE MASON UNIVERSITY · 2024 · $580,872 — The overdose crisis in the United States is continually evolving and rapid knowledge generation is critical to preventing unnecessary deaths and promoting public health. The Rapid Response and Pilot Research (RRPR) Core seeks to respond to this challenge of generating evidence that can quickly be ad…

SDSU FUERTE: Administrative Core

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Mark Brian Reed · SAN DIEGO STATE UNIVERSITY · 2024 · $32,982 — ADMINISTRATIVE CORE – Project Summary Human health is negatively impacted by the lack of gender, racial, and ethnic diversity in biomedical and health sciences research in the United States. This lack of diversity adversely impacts discovery, innovation, and the advancement of scientific knowledge. …

Leadership, Planning and Evaluation (LPE)

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Robert A. Winn · VIRGINIA COMMONWEALTH UNIVERSITY · 2024 · $338,277 — LEADERSHIP, PLANNING, AND EVALUATION: PROJECT SUMMARY The Virginia Commonwealth University (VCU) Massey Cancer Center (MCC) Senior Leadership and its multi- level planning and evaluation structures are instrumental to the Center’s ability to identify and prioritize new strategic opportunities for gr…

Prototype strategy for vaccines and antibodies to rubulaviruses

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

William Paul Duprex · WASHINGTON UNIVERSITY · 2024 · $5,674,171 — Project 2: Abstract Rubulaviruses are respiratory pathogens with a high level of transmissibility (R0 = 4-7). MuV is an ideal prototype pathogen to study paramyxoviruses because we have a human vaccine that elicits protective humoral immunity directed to undefined target(s). P2-Rubulaviruses dissect…

Critical effects associated with developmental PFAS exposure profiles

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

PHILIPPE ADAM GRANDJEAN · UNIVERSITY OF RHODE ISLAND · 2024 · $369,926 — PROJECT SUMMARY/ABSTRACT – PROJECT 2 CRITICAL EFFECTS Metabolic diseases, including obesity and type 2 diabetes, are major public health problems of multifactorial etiology, in which early-life exposures to environmental pollutants, such as per- and polyfluoroalkyl substances (PFAS), appear to play …

Data and Methods Core

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Rosalie Liccardo Pacula · RAND CORPORATION · 2024 · $1,176,489 — DATA & METHODS CORE ABSTRACT Researchers and policymakers need better data, improved methods, and rigorous analysis to best determine which policies and initiatives are, or could be, effective in addressing the nation’s opioid-related public health crisis. Research assessing the effectiveness of spe…

University of South Florida Site Consortium - Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN) Operations and Collaborations Center (UM2 Clinical Trial Optional)

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

PATRICIA J EMMANUEL · WESTAT, INC. · 2024 · $468,658 — ABSTRACT University of South Florida The USF Adolescent HIV Consortium will collaborate with the Adolescent Trials Network (ATN) Operations and Collaborations Center (OCC) by engaging, enrolling, and retaining adolescents and young adults, both at risk of and living with HIV, in care and research th…

Core 09: Ethics and Regulatory Knowledge Core

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Leigh Lamonica · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · 2024 · $89,997 — The overarching goal of the Ethics and Regulatory Knowledge (ERK) Core of the Louisiana Clinical and Translational Science Center (LA CaTS) is to create a unified systematic approach to the conduct of clinical and translational research across Louisiana. We will build on the successful research infr…

Core 04: Pilot Projects Program

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

AUGUSTO C. OCHOA · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · 2024 · $389,644 — The goal of the Pilot Projects Program (PPP) Core is to increase the number of junior investigators trained in clinical and translational research that work with well-established teams of senior scientists developing innovative research programs to address the chronic disease burden in Louisiana. Th…

Core 06: Biomedical Informatics Core

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Lucio Miele · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · 2024 · $287,706 — The overall goal of the Biomedical Informatics (BMI) Core of the Louisiana Clinical and Translational Science Center (LA CaTS) is to build on our accomplishments and continue to develop and deploy “state of the art” informatics services to LA CaTS investigators. During the current funding period, th…

Rodent Phenotyping Core

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Michael G Anderson · UNIVERSITY OF IOWA · 2024 · $179,813 — PROJECT SUMMARY The goal of the Rodent Phenotyping Core (RPC) is to increase the utility of mice and rats as model organisms for vision research at The University of Iowa. The availability of a centralized core for phenotyping will allow investigators to focus their resources on the science and disc…

Research Core 1: Molecular Measures Core (RC1)

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Virginia Kraus · DUKE UNIVERSITY · 2024 · $674,676 — PROJECT SUMMARY – Molecular Measures Core (MMC) The Molecular Measures Core (MMC) provides a centralized resource, analytical tools and expertise to measure a broad array of molecular analytes in support of Duke OAIC projects in their work to understand and optimize reserve and resilience. The MMC h…