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9873 documents

DREAMS - Translational Research Core - Health Equity & Action Translational (HEAT)

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Alyce Sophia Adams · KAISER FOUNDATION RESEARCH INSTITUTE · 2024 · $130,292 — Project Summary/Abstract: Health Equity & Action Translational (HEAT) Research Core There is growing recognition that, in order to promote health equity across the diabetes continuum, a new generation of translational research must address system and policy level drivers of inequities. As one of two…

Implementation Science and Equity: Community Engagement & Outreach (CEO) Core

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Elizabeth Ann Calhoun · UNIVERSITY OF KANSAS MEDICAL CENTER · 2024 · $178,035 — PROJECT SUMMARY/ABSTRACT: COMMUNITY ENGAGEMENT & OUTREACH (CEO) CORE Engaging with patients, families, caregivers, neighborhoods, and communities is an essential feature of implementation research. Meaningful engagement requires trust, which comes from sustained collaboration over time. In the case …

Strengthening COVID-19 prevention strategies via wastewater surveillance in a Northern Plains Tribe

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Jeffrey A Henderson · BLACK HILLS CTR/AMERICAN INDIAN HEALTH · 2024 · $515,432 — Despite the abundance of clinical and epidemiologic data collected during this pandemic, relatively little focus has been paid to the examination of infectious agents through bulk wastewater detection and epidemiological data that is particularly well-suited for disease surveillance in remote, front…

UAB CFRC Administrative Core

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

David M. Bedwell · UNIVERSITY OF ALABAMA AT BIRMINGHAM · 2024 · $139,562 — PROJECT SUMMARY/ABSTRACT The UAB Cystic Fibrosis Research and Translation Core Center Administrative Core is responsible for the overall administration and coordination of the Biomedical Research Cores, Pilot & Feasibility Program, and Enrichment Program. The Administrative Core is directed by Drs. …

Core D: Special Populations

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

CURT G BECKWITH · RHODE ISLAND HOSPITAL · 2024 · $331,910 — PROJECT SUMMARY The Community Engaged Research Core (CERC) of the COBRE on Opioids and Overdose, formerly the Special Populations Core in Phase 1, promotes research among people who are impacted by opioids and overdose, particularly people who are vulnerable and underserved. The CERC supports the ov…

Dissemination Core

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Nitika Pai · CORNELL UNIVERSITY · 2024 · $257,058 — Point of Care Technologies for Nutrition, Infection and Cancer for Global Health (PORTENT) 5.0 Dissemination Core Abstract The PORTENT center represents a novel and rigorous approach to the development, deployment, and commercialization of point-of-care technologies for global health. With the COVI…

Community Engagement Core

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

David Sane Martins · CHARLES R. DREW UNIVERSITY OF MED & SCI · 2024 · $308,289 — ABSTRACT COMMUNITY ENGAGEMENT CORE (CEC) Research collaborations and partnerships are invaluable to CDU investigators to facilitate the exploration of scientific arenas that lie beyond their areas of expertise and expand translational research. The university holds a rich history of successful partn…

Research Capacity Core

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

JAMES M WACHIRA · MORGAN STATE UNIVERSITY · 2024 · $833,146 — PROJECT SUMMARY – Research Capacity Core The proposal aims to provide resources and expertise to enhance biomedical research quality and productivity through a Morgan State University (MSU) RCMI Research Capacity Core (RCC). With current funding support by NIMHD/RCMI and NIH/NIGMS/BUILD, MSU has est…

Biospecimens Core

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

MICHAEL S TORBENSON · MAYO CLINIC ROCHESTER · 2024 · $336,496 — BIOSPECIMEN AND PATHOLOGY CORE C – PROJECT SUMMARY The Biospecimen and Pathology Core (Core C) collects and annotates biospecimens with clinical data to meet the needs of the three Translational Research Projects, Developmental Research and Career Enhancement Programs, and investigators engaged in h…

Project 2: Interrogating immuno-metabolic programs using a novel Flow Cytometry based  assay to reveal novel T cell subsets in SARS-CoV-2 infected patients

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

JONATHAN D POWELL · JOHNS HOPKINS UNIVERSITY · 2024 · $126,657 — The metabolic activity of immune cells is tightly linked to their function. We have been developing a flow cytometry based platform that enables single cell analysis of traditional cell surface markers combined with intracellular staining for proteins involved in metabolic programming. The intracell…

Core A: Administrative Core

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Ralph S Baric · UNIV OF NORTH CAROLINA CHAPEL HILL · 2024 · $136,801 — Abstract The overall purpose of the FOA is to “establish Serological Sciences Centers of Excellence with the goal of identifying and advancing research opportunities to characterize the immune responses elicited by SARS-CoV- 2 viral infection”. The “UNC Center for Excellence in SARS-CoV2 Serologic R…

Core B: Shared Resource Core For Characterizing Antibody Responses To SARS-CoV-2 And Other Pathogenic Human Coronaviruses

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Aravinda M. DeSilva · UNIV OF NORTH CAROLINA CHAPEL HILL · 2024 · $136,800 — Abstract High-quality recombinant antigens and reliable and accurate SARS-CoV-2 serological assays are urgently needed for surveillance and for defining the immune mechanisms of viral pathogenesis, viral clearance, and protection against reinfection. Core B of the UNC SARS-CoV-2 Serological Sciences…

To Develop and Manufacture an Inactivated SARS-CoV-2 Vaccine Using Blood Pathogen Reduction Technology

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

RAYMOND GOODRICH · COLORADO STATE UNIVERSITY · 2024 · $850,444 — To support the advanced development of candidate products for use following the intentional release of or in response to naturally occurring outbreaks of infectious diseases, including emerging infectious diseases. This contract may support formulation and manufacture of the individual vaccine compo…

CEIRR Data Processing and Communications Center Activities for SARS-CoV-2

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

STEPHAN BOUR · DIGITAL INFUZION, INC. · 2024 · $283,056 — CEIRR will determine the molecular, ecologic and/or environmental factors that influence the evolution, emergence, transmission and pathogenicity of respiratory viruses, including coronaviruses such as SARS-CoV-2, and characterize the immune response to infection to improve understanding of the immu…

CEIRR: SARS-CoV-2 Research Activities

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

SCOTT HENSLEY · UNIVERSITY OF PENNSYLVANIA · 2024 · $1,174,838 — CEIRR will determine the molecular, ecologic and/or environmental factors that influence the evolution, emergence, transmission and pathogenicity of respiratory viruses, including coronaviruses such as SARS-CoV-2, and characterize the immune response to infection to improve understanding of the immu…

COPD(GENE): TASK B: "STEWARDSHIP OF BIOSPECIMEN AND DATA REPOSITORIES"

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

James D Crapo · NATIONAL JEWISH HEALTH · 2024 · $922,055 — Chronic obstructive pulmonary disease (COPD) is a syndrome commonly defined by a single physiological feature–chronic airflow obstruction. To improve diagnosis and treatment of COPD, it is essential to divide this complex syndrome into biologically meaningful subgroups of COPD patients and to predic…

Administrative Core

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Kevin Sean Kimbro · MOREHOUSE SCHOOL OF MEDICINE · 2024 · $368,812 — Abstract In congruence with the mission of the NIMHD funded RCMI program, the Morehouse School of Medicine (MSM) has continued to address health equity. In alignment with the MSM Strategic Plan, the Administrative Core (Admin. Core) will develop and strengthen the research infrastructure necessary t…

Centers for Research on Structural Biology of Infectious Diseases: Coronavirus

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

PETER MYLER · SEATTLE CHILDREN'S HOSPITAL · 2024 · $366,698 — To apply state-of-the-art, high-throughput structural biology technologies to experimentally characterize the three-dimensional atomic structure of targeted proteins on the NIAID priority pathogens list and organisms causing emerging and re-emerging infectious diseases. This program also supports re…

Centers for Research on Structural Biology of Infectious Diseases: SARS-CoV-2

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

KARLA SATCHELL · NORTHWESTERN UNIVERSITY AT CHICAGO · 2024 · $3,052,532 — To apply state-of-the-art, high-throughput structural biology technologies to experimentally characterize the three-dimensional atomic structure of targeted proteins on the NIAID priority pathogens list and organisms causing emerging and re-emerging infectious diseases. This program also supports re…

Role of Endothelial eNAMPT/NAMPT secretion and TLR4 signaling in the ARDS Vascular Endotype

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Joe G. N. Garcia · UNIVERSITY OF FLORIDA · 2024 · $297,844 — ABSTRACT: The global COVID-19 pandemic has dramatically highlighted the critical role of lung vascular inflammation and multi-organ endothelial cell (EC) permeability in ARDS mortality and the unprecedented COVID-19-ARDS vas- cular endotype (1). This A1 Project #2 application remains focused on the …