Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Ignacio E. Sanz · EMORY UNIVERSITY · 2020 · $525,608 — The COVID19 pandemic illustrates the urgent need for understanding human B cell responses to emergent pathogens and its application to assessing herd immunity. Our laboratories have described the phenotypic, immunological and molecular features of different arms of human B cell responses and in part…
Michael B Sporn · TRITERPENOID THERAPEUTICS, INC. · 2020 · $249,799 — PROJECT ABSTRACT COVID-19 infection is associated with substantial mortality in patients with clinical co-morbidities, including smoking, advanced age and diabetes mellitus. In these patients, COVID-19 infection leads to a hyperinflammatory state producing vascular leak, interstitial edema, hyaline …
Babafemi O Taiwo · NORTHWESTERN UNIVERSITY AT CHICAGO · 2020 · $814,136 — Parent Award Project Summary The Chicago Clinical Trials Unit (CCTU) is a consortium of five Clinical Research Sites (CRSs) which will address three priority clinical research areas of the NIAID: 1) adult HIV therapeutic strategies including HIV cure, noninfectious comorbidities, and infectious co-m…
Andrea L. Roberts · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · 2020 · $574,134 — PROJECT SUMMARY Children of women exposed to childhood abuse exhibit increased risk for a wide array of neurodevelopmental deficits and are at elevated risk of anxiety, depression, autism, and attention deficit disorder (ADHD). The parent grant seeks to identify biological dysregulation during pregn…
Oliver Brand · EMORY UNIVERSITY · 2020 · $11,194,205 — The advent of point-of-care (POC) diagnostic capabilities has enabled rapid and timely clinical evaluation in the physician's office, an ambulance, the home, the field, or in the hospital and has the potential to significantly impact health care delivery. In cardiology, pulmonology/critical care, an…
Nitin S Baliga · INSTITUTE FOR SYSTEMS BIOLOGY · 2020 · $661,549 — Project Summary The NIAID national protocol intends to enroll at least 1000 COVID19 patients in a study designed to track infected patients through tracking, over time, their immune responses, viral load, and a variety of multi-omic analytes that can provide deep insights into how infection by SARS-…
ROBERT E BRAUN · JACKSON LABORATORY · 2020 · $925,466 — PROJECT SUMMARY In response to “NOT-RM-20-015”, we propose an urgent competitive revision to The Jackson Laboratory Knockout Mouse Phenotyping Project (KOMP2) to develop the next generation of precision mouse models for mechanistic discovery of SARS-CoV2 infection and therapeutic discovery of COVID-…
DAVID D. CELENTANO · JOHNS HOPKINS UNIVERSITY · 2020 · $159,411 — ABSTRACT Current data suggest a disproportionate burden of COVID-19 illness and death among racial and ethnic minority groups.1,2 In multiple urban cities across the United States (U.S.) Black and Latinx persons are disproportionately impacted by COVID-19 illness and death.1,3-5 Disproportionate rat…
BRYAN R KESTENBAUM · UNIVERSITY OF WASHINGTON · 2020 · $500,000 — PROJECT ABSTRACT Coronavirus disease 2019 (COVID-19) is a global pandemic caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). SARS-CoV-2 has been identified within multiple cell types of the kidneys, including tubular epithelial cells, endothelial cells, and podocytes, sugges…
Jeremy James Martinson · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2020 · $359,561 — COVID-19 and the MWCCS: Pathophysiology, Impact and Outcomes ABSTRACT COVID-19 cases continue to rise, with over 3,000,000 cases and 130,000 deaths in the US[1] and almost 12 million cases worldwide[2] to date. Manifestations of SARS CoV-2 infection range from asymptomatic to mild, moderate, or seve…
JOSEPH P MIZGERD · BOSTON UNIVERSITY MEDICAL CAMPUS · 2020 · $716,519 — Project Summary COVID-19 is a pressing crisis. The responsible coronavirus, SARS-CoV-2, is highly infectious, spreads rapidly, and causes severe disease requiring hospitalization, critical care, or mechanical ventilation. However, even for SARS-CoV-2, only a minority of cases are severe. The biologi…
MARK A. ATKINSON · UNIVERSITY OF FLORIDA · 2020 · $1,351,492 — Extensive clinical research studies are urgently needed to inform patient management strategies and develop pharmaceutical countermeasures to combat the 2019 novel coronavirus disease (COVID-19). Currently, COVID-19 infections and hospitalizations are surging across the state of Florida; hence, we p…
Robert J Carroll · BROAD INSTITUTE, INC. · 2020 · $217,232 — PROJECT SUMMARY In response to the COVID-19 pandemic, the Host Genetics Initiative (HGI) has formed to generate, share, and analyze data to identify the underlying genetic determinants of the SARS-CoV-2 infection and disease, including the severity in symptomatic presentation and associated outcomes…
Lawrence Corey · FRED HUTCHINSON CANCER RESEARCH CENTER · 2020 · $393,953,893 — This proposal outlines the scientific agenda for the Leadership and Operations Center of the HIV Vaccine Trials Network (HVTN), the collaboration of physician scientists at 64 clinical trial sites in 15 countries on 4 continents dedicated to developing globally effective vaccines for HIV, tuberculos…
MATHEW S MAURER · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2020 · $176,033 — Project Summary COVID-19 is a global pandemic that disproportionately affects minority older adults with cardiac disease and multiple chronic conditions. Densely populated urban centers with a high proportion of socioeconomically disadvantaged persons, including New York City (NYC) and Boston, are m…
Hooman Kamel · YALE UNIVERSITY · 2020 · $502,754 — Atrial fibrillation, the most common heart-rhythm disorder, increases the risk of ischemic stroke by 3- to 5-fold. Anticoagulant therapy has been proven to prevent 60-80% of ischemic strokes that would otherwise occur from atrial fibrillation. Patients with a history of intracerebral hemorrhage have…
Lynn T Singer · CASE WESTERN RESERVE UNIVERSITY · 2020 · $161,000 — PROJECT SUMMARY The Planning for the HEALthy Early Development Study will contribute to the design and recommended protocol for a future large-scale, multi-site research study to prospectively examine human brain, cognitive, behavioral, social and emotional development of children beginning prenatal…
Pamina Mae Gorbach · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2020 · $326,106 — ABSTRACT In response to the Notice of Special Interest (NOSI) regarding the Availability of Administrative Supplements and Urgent Competitive Revisions for Research on the 2019 Novel Coronavirus (Notice Number NOT-DA-20-047 and linked Program Announcement PA-18-591) funding opportunity, the Collabor…
Peter B. Gilbert · FRED HUTCHINSON CANCER RESEARCH CENTER · 2020 · $401,609 — This proposal outlines the scientific agenda for the Leadership and Operations Center of the HIV Vaccine Trials Network (HVTN), the collaboration of physician scientists at 64 clinical trial sites in 15 countries on 4 continents dedicated to developing globally effective vaccines for HIV, tuberculos…
Kathleen Engelman · UNIV OF MASSACHUSETTS MED SCH WORCESTER · 2020 · $323,571 — Project Summary The Nonhuman Primate Reagent Resource (NHPRR) develops recombinant biological materials to support research with animal models of human diseases. In our parent P40 award, we produce and distribute approximately 400g of recombinant protein reagents per year. Therefore, we have the too…