Combined archive search across FBI Vault, SPLC, PHMPT, ACIP, NIH grants, the Federal Writers' Project, and other collections we've ingested.
KARLA SATCHELL · NORTHWESTERN UNIVERSITY AT CHICAGO · 2022 · $238,466 — To apply state-of-the-art, high-throughput structural biology technologies to experimentally characterize the three-dimensional atomic structure of targeted proteins on the NIAID Category A-C priority pathogens list and organisms causing emerging and re-emerging infectious diseases. This program als…
DAVID LINDSAY · LEIDOS BIOMEDICAL RESEARCH, INC. · 2022 · $9,822,408 — The Vaccine Research Center (VRC) mission and scope includes rapidly moving clinical candidates from the research bench through development and GMP manufacturing to the clinic. The VRC is exploring a wide range of initiatives, including but not limited to new technologies which would decrease the ti…
BARRY GAUSE · LEIDOS BIOMEDICAL RESEARCH, INC. · 2022 · $1,200,000 — COVID SARS-CoV-2 Assessment Viral Evolution (SAVE) variant testing provides support for analysis of SARS-CoV-2 genome sequences from specimens collected in COVID-19 therapeutic and observational trials for genetic variants that could impact diagnostics, therapeutics, vaccine efficacy, and disease se…
Tony Dickherber · NATIONAL CANCER INSTITUTE · 2022 · $2,129,500 — In May 2020, in response to the rapidly expanding pandemic caused by the SARS-CoV-2 virus, the National Cancer Institute (NCI) and the National Institute of Biomedical Imaging and Bioengineering (NIBIB) launched a program called Digital Health Solutions for COVID-19. The goal of this initiative was …
PAUL J CHUNG · KAISER FOUNDATION RESEARCH INSTITUTE · 2022 · $132,460 — PROJECT SUMMARY/ ABSTRACT Although universal early childhood developmental screening is recommended by the American Academy of Pediatrics, ample evidence suggests that child health providers are not meeting those recommendations, and many early developmental delays are being missed. Additional evide…
Nicholas J. Mantis · WADSWORTH CENTER · 2022 · $592,301 — Project Summary As the COVID-19 pandemic continues to spread across the United States it is imperative that we implement technologies to screen large swaths of the population for the presence of antibodies to SARS-CoV-2. Serological surveillance not only affords a measure of virus exposure within a …
JODI K CRAIGO · CYTOAGENTS, INC. · 2022 · $1,000,000 — Abstract CytoAgents is developing GP1681 (beraprost-314d) to regulate the uncontrolled inflammatory response that can result from viral infections. This inflammatory response is associated with increased disease severity, acute lung injury (ALI), acute respiratory distress syndrome (ARDS), and death…
Karen Marie Dobos · COLORADO STATE UNIVERSITY · 2022 · $3,193,195 — Project Summary / Abstract The funding and implementation of this supplement is essential to maintain uninterrupted research and scholarly activity in CSU’s Rocky Mountain Regional Biocontainment Laboratory (RMRBL). Research activities that occur at the RMRBL directly address the RBLs’ missions to r…
James D Weger · VIRGINIA POLYTECHNIC INST AND ST UNIV · 2022 · $190,284 — Project Summary/Abstract Chikungunya virus (CHIKV), an NIAID category B pathogen, causes a debilitating arthritic disease that can last for years. A massive outbreak of CHIKV occurred throughout the Americas in 2013, with an estimated 39.9 million people infected. Closely related viruses include Ro…
Diego G Diel · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · 2022 · $778,213 — The ongoing pandemic of COVID-19 is designated by World Health Organization (WHO) as a Public Health Emergency of International Concern. Similarities among ACE2 receptors predict that there are several animals could function as reservoirs for the virus. Recent studies by us and others identified fel…
Gary Kobinger · UNIVERSITY OF TEXAS MED BR GALVESTON · 2022 · $7,131,815 — PROJECT SUMMARY/ABSTRACT Toward maintaining and improving pandemic preparedness, we propose value-added facility upgrades that better integrate the high-containment communities at the University of Texas Medical Branch (UTMB), Galveston. UTMB laboratories integrate operations through joint-facility …
Hardy Kornfeld · UNIV OF MASSACHUSETTS MED SCH WORCESTER · 2022 · $3,994,219 — Program Summary/Abstract The University of Massachusetts Chan Medical School (UMass Chan) seeks NIH G20 funding to repair, renovate, and modernize the existing Biosafety Level 3 (BSL3) and Animal BSL3 (ABSL3) facilities to enhance current research on RNA viruses of pandemic potential. As an internat…
Soo-Jeong Lee · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2022 · $201,875 — PROJECT SUMMARY/ABSTRACT Disinfectants are widely used in various products and in various settings to prevent infection and transmission of harmful pathogens. Disinfectants, however, contain hazardous chemicals and are known to cause irritation or allergic symptoms in eyes, skin, respiratory and ner…
Alan Tackett · ARKANSAS CHILDREN'S HOSPITAL RES INST · 2022 · $770,000 — Summary In July of 2017, we launched Phase I of the COBRE Center for Translational Pediatric Research at Arkansas Children’s Research Institute in Little Rock, Arkansas. The mission of the center is to use proteogenomic approaches to identify epigenomic mechanisms and therapeutic targets in disease…
Jonathan Andrew Kropski · FEDERATION OF AMER SOC FOR EXPER BIOLOGY · 2022 · $40,000 — Project Summary The 2022 FASEB Summer Research Conference, "The Lung Epithelium in Health and Disease", is the 11th biannual conference in this area, bringing together developmental, cell and molecular biologists, geneticists, physiologists, clinicians and translational researchers with a primary in…
LISA A JACKSON · KAISER FOUNDATION RESEARCH INSTITUTE · 2022 · $2,114,527 — The 21-0004 protocol will evaluate the safety and immunogenicity of SARS-CoV-2 administered during pregnancy or postpartum. The Seattle Children’s Research Institute, a subcontractor to the Kaiser Washington VTEU, has been selected to perform SARS-CoV-2 pseudovirus neutralization assays for the 21-0…
Deborah J Donnell · FRED HUTCHINSON CANCER CENTER · 2022 · $389,142 — Abstract The proposed research, CoVPN 5002, will directly contribute to preparedness for SARS-CoV-2 vaccine and other COVID-19 prevention and treatment studies by determining the prevalence of SARS-CoV-2 infection and seroprevalence among samples of individuals at elevated risk as well as the genera…
Larry S. Schlesinger · TEXAS BIOMEDICAL RESEARCH INSTITUTE · 2022 · $7,483,557 — OVERALL ABSTRACT The Mission of the Southwest National Primate Research Center (SNPRC) is to improve the health of our global community through innovative biomedical research with nonhuman primates (NHPs). One way that it achieves this goal is by serving as a global resource to scientists that ca…
PAUL A WADE · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · 2022 · $3,185,628 — The Epigenomics and DNA Sequencing Core Lab provides a variety of services to the NIEHS scientific community. For next-generation sequencing, the core produces hundreds of millions of short sequence reads of individual DNA molecules using the Illumina NovaSeq 6000, NextSeq 500 or Illumina's MiSeq pl…
Steven Holland · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2022 · $2,596,620 — The major activities of this research project in the past have centered around using our optimized methods and procedures for imaging rhesus macaques, NZW rabbits, and common marmosets on PET/CT scanners while conducting a variety of chemotherapy and basic immunology experiments in Mtb models. We ha…