Combined archive search across FBI Vault, SPLC, PHMPT, ACIP, NIH grants, the Federal Writers' Project, and other collections we've ingested.
Jody M. Ganiban · UNIVERSITY OF OREGON · 2024 · $1,748,806 — Project Summary The combined economic and personal effects of children’s neurodevelopmental problems, such as conduct disorder, ADHD, and depression and anxiety symptoms are substantial. At the same time, there is growing evidence that dimensions of positive health can support children in leading me…
Sergio Dominguez Lopez · STATE UNIVERSITY OF NEW YORK AT BUFFALO · 2024 · $249,000 — Project Summary/Abstract This proposal is being submitted to support the transition of Dr. Dominguez-Lopez from mentored trainee to an independent investigator in the neurobiology of drug addiction, specifically studying the dopamine microcircuits controlling drug-seeking behavior. Dr. Dominguez-Lop…
BRAD FORTUNE · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2024 · $42,854 — PROJECT SUMMARY / ABSTRACT During development, specific synaptic partners connect in order to ensure proper neural circuit function, but how these connections are disassembled during neurodegeneration is less well understood. In rodent experimental glaucoma (EG) models, synapse loss occurs early, p…
Meghan Chenoweth · CENTRE FOR ADDICTION AND MENTAL HEALTH · 2024 · $144,521 — Project Summary Substance use and other psychiatric disorders result in enormous personal, healthcare, and economic costs. Substance use (e.g., tobacco use disorder) and psychiatric (e.g., schizophrenia) disorders are highly comorbid. Three main theories have been proposed to explain the high comor…
PANDU R GANGULA · MEHARRY MEDICAL COLLEGE · 2024 · $145,500 — Diabetes Mellitus (DM) and periodontal diseases (PD) are complex chronic diseases with an established bidirectional relationship. People with PD have two to three times the risk of having a heart attack, stroke, or serious cardiovascular complications. PD in individuals with diabetes contributes to …
CHRISTOPHER KABRHEL · MASSACHUSETTS GENERAL HOSPITAL · 2024 · $568,519 — Background: Acute pulmonary embolism (PE) can cause a sudden rise in pulmonary artery (PA) pressure and right ventricular dysfunction (RVD), which can lead to circulatory collapse and death. Increased PA pressure and RVD results from mechanical obstruction by thrombus, but also pulmonary artery (PA)…
Matthew James Smith · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2024 · $807,005 — Project Summary: Pre-employment transition services is federally-mandated by the Workforce Innovation and Opportunities Act (2014) to help prepare autistic transition-age youth for the workforce prior to existing high school. However, there are few evidence-based practices implemented within pre-emp…
Ewan Kemar Cobran · MAYO CLINIC ARIZONA · 2024 · $168,264 — Project Summary/Abstract Novel genomic technology, such as microarray analyses and next-generation sequencing, have improved the understanding of prostate cancer biology and prognosis. The National Comprehensive Cancer Network (NCCN), in 2016, recommended that patients and clinicians consider tissue…
Jeremy A Elser · SHIP OF THESEUS, LLC · 2024 · $213,500 — Hematopoietic stem cell (HSC) transplants (HSCTs) are considered a potentially curative option for patients with certain cancers of the blood and bone marrow and over 20,000 HSCTs are performed in the US each year. However, HSCTs are associated with high risk due to the required removal of diseased …
Elizabeth C. Matsui · UNIVERSITY OF TEXAS AT AUSTIN · 2024 · $237,750 — Project Summary Mexican American children are the only demographic group whose asthma prevalence is increasing and Mexican American children with asthma have a ~2-3-fold greater risk of being hospitalized than their non- Latinx white counterparts. This excess burden of morbidity affects the ~ 200,00…
Kenneth L Pitter · OHIO STATE UNIVERSITY · 2024 · $393,750 — PROJECT SUMMARY/ABSTRACT Individual cells within a given cancer type are capable of expressing a diversity of phenotypic states resulting from an underlying heterogeneity of genetic, epigenetic, transcriptomic, and molecular features. How this diversity evolves and influences therapeutic response is…
Tonya Bloomer Van Deinse · UNIV OF NORTH CAROLINA CHAPEL HILL · 2024 · $155,556 — PROJECT SUMMARY/ABSTRACT People with serious mental illnesses (SMI) are disproportionately represented throughout the criminal justice system, the vast majority of whom are on probation and parole. Implementing evidence-based practices to address the needs of justice-involved people with SMI require…
LISA Allyn BOARDMAN · MAYO CLINIC ARIZONA · 2024 · $575,706 — Project Summary Abstract Colorectal cancer (CRC) is among the most common malignancy worldwide and has a high mortality rate. In spite of advances in our understanding of the genetics and immunology of CRC, it remains largely resistant to therapy. Colonization of the large intestine by oral microbes…
Alexander Gitlin · SLOAN-KETTERING INST CAN RESEARCH · 2024 · $442,500 — Project Summary/Abstract Rare monogenic immune disorders have illuminated key aspects of inflammation, but many of the underlying mechanisms remain poorly understood. For example, autoimmune lymphoproliferative syndrome (ALPS), a disorder in which T cells fail to undergo apoptosis, is most often cau…
Nan Yan · UT SOUTHWESTERN MEDICAL CENTER · 2024 · $467,088 — Niemann-Pick disease type C (NPC) is a fatal neurodegenerative disease caused by genetic mutations in the NPC1 (95%) and NPC2 (5%) genes. Neurological features of NPC bear striking resemblances with Alzheimer’s disease (AD), leading to some experts considering NPC as “Childhood Alzheimer’s”. No FDA-…
DOMINIQUE M DURAND · CASE WESTERN RESERVE UNIVERSITY · 2024 · $377,984 — Abstract A seizure is an abnormal neural activity in the brain and the main characteristic of epilepsy. About one-third of the patients have seizures resistant to anti-epileptic medication and therefore, an alternative treatment is necessary. Recent studies show that neurons can be recruited and sei…
Yisong Guo · CARNEGIE-MELLON UNIVERSITY · 2024 · $341,407 — Project Summary/Abstract Iron and 2-oxoglutarate-dependent (Fe/2OG) enzymes, representing a superfamily of non-heme mononuclear iron-containing (NHM-Fe) enzymes, have garnered strong research interests from fundamental enzyme mechanism studies to bioengineering/biocatalysis explorations in recent ye…
Katherine Aboud · VANDERBILT UNIVERSITY · 2024 · $396,250 — PROJECT SUMMARY Approximately 43 million adults in the U.S. struggle to comprehend basic texts. This is a major public health crisis given the strong association between reading comprehension (RC) ability and broad health and economic outcomes, including more than 300 billion annual economic burden …
Maria Aisha Jones-Muhammad · UNIVERSITY OF ALABAMA AT BIRMINGHAM · 2024 · $77,859 — Project Summary Preeclampsia, a hypertensive disorder of pregnancy, can advance to eclampsia, when the mother displays novel seizures. The mechanisms that cause some preeclampsia patients to advance to eclampsia are unknown. The long-term goals are to identify therapeutic targets to prevent seizures…
ERIC JAMES KEZIRIAN · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2024 · $590,974 — We propose to conduct a prospective cohort (observational) study of 150 participants with moderate to severe obstructive sleep apnea (OSA) unable to tolerate positive airway pressure who are undergoing drug-induced sleep endoscopy (DISE), including measurement of upper airway closing pressure (Pclos…