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9873 documents

ASSESSING THE EVOLVING IMPACT OF EARLY LIFE EXPOSURES ON CHILD PHYSICAL HEALTH AND NEURODEVELOPMENT

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Viren Andrew D'Sa · RHODE ISLAND HOSPITAL · 2024 · $1,995,044 — PROJECT SUMMARY / DESCRIPTION How does a healthy child grow? Asked by every parent, the simplicity of this question masks the complex nature of child development and makes light of the diverse environmental factors and variables that shape a child’s emerging physical health and neurodevelopment. Beg…

University of California, Davis: Human Papillomavirus Cancer Free (UCD: HPV Cancer Free)

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Julie Dang · UNIVERSITY OF CALIFORNIA AT DAVIS · 2024 · $167,940 — This K01 award resubmission outlines an intensive five-year research career development program focused on multilevel behavioral intervention and dissemination and implementation science research to increase and sustain uptake of the human papillomavirus (HPV) vaccine. Supporting the candidate's car…

Isolation and Loneliness Underlying Misuse and Increased Use of Alcohol as a function of Stress and Coping Efforts

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

MICHAEL FENDRICH · UNIVERSITY OF CONNECTICUT STORRS · 2024 · $452,356 — The IsoLation and Loneliness Underlying Misuse and INcreased use of Alcohol as a function of sTress and coping Efforts (ILLUMINATE) project will test adaptive/maladaptive coping as the mechanisms of action linking objective social isolation and subjective feelings of loneliness with alcohol use/misu…

Evaluation of an Asynchronous Remote Communities Approach to Behavioral Activation for Depressed Adolescents

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Jessica Lynne Jenness · UNIVERSITY OF WASHINGTON · 2024 · $237,496 — PROJECT SUMMARY Approximately 3.1 million adolescents are diagnosed with depression each year with over 60% not receiving or engaging in mental health care. In an effort to address the significant challenges in access to and engagement with evidence-based psychosocial interventions (EBPIs) for adole…

The Impact of COVID-19 on Parent and Child Well-Being in Early Childhood

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Kierra Marie Pettit Sattler · UNIVERSITY OF NORTH CAROLINA GREENSBORO · 2024 · $441,018 — Modified Project Summary/Abstract Section Multisystem disasters confer risk across socioecological levels, changing nearly every aspect of life. Research has started to document how multisystem risks impact parents and children; however, much of the research does not assess the multi-dimensional na…

Elucidating the legacy of early parent-child relationship: A new developmental synthesis of temperament, internal representation, and behavior

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

GRAZYNA KOCHANSKA · UNIVERSITY OF IOWA · 2024 · $644,910 — ABSTRACT The overarching goal of this research is to promote children’s positive socioemotional pathways and to prevent maladaptive pathways. We elucidate why some children embark on positive paths toward prosocial, internalized, rule-abiding conduct, and robust social competence, whereas others ent…

FY21 ITCA NARCH XI

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Maria Dadgar · INTER TRIBAL COUNCIL OF ARIZONA, INC. · 2024 · $1,205,776 — NARCH Overall Abstract The overall goal of the Center is to support health research projects that benefit Tribal Members, develop relationships to enhance tribal governance and partnerships in health research, conduct research that honors Tribal sovereignty, and promote a cadre of AI/AN researchers …

Social Media Use, Sleep, and Suicidality in Adolescents

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

NICOLE R NUGENT · BROWN UNIVERSITY · 2024 · $923,457 — Project Summary Adolescent suicide rates have increased over the past two decades, with the recent COVID-19 exacerbating pre-pandemic risk factors including increases in online social messaging. We propose that online social messaging for adolescents serves as a “social zeitgeber” (an environmental …

Evaluation of Novel Technologies to Improve Clinical Management of Celiac Disease: The GLUTECH Trial

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Benjamin Lebwohl · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2024 · $1,333,964 — PROJECT SUMMARY The proposed project addresses the need for a rigorous trial to test the effectiveness of novel gluten detection technologies as an adjunct to telemedicine to manage celiac disease in adults. Celiac disease affects about 1% of the United States (U.S.) population and seroprevalence ha…

Fair risk profiles and predictive models for outcomes of obstructive sleep apnea through electronic medical record data

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Victor Borza · VANDERBILT UNIVERSITY · 2024 · $34,164 — PROJECT SUMMARY Obstructive sleep apnea (OSA) is a sleep-related breathing disorder associated with major co-morbidities and is estimated to affect nearly one billion people worldwide. Moreover, there are differences in prevalence, diagnosis rates, and co-morbid outcomes for OSA based on the demogra…

Preventing disruptions in progress towards ending HIV/AIDS: Lessons from the COVID-19 pandemic

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Danielle Giovenco · EMORY UNIVERSITY · 2024 · $177,304 — PROJECT SUMMARY Public health emergencies, including conflict, natural disasters, and local and global epidemics and pandemics, have the potential to disrupt progress towards ending the HIV/AIDS epidemic. Understanding the impact that these disruptive events have on the HIV epidemic over time is ess…

Effective Primary care practices that Enhance Recovery Trajectories after pneumonia (EXPERT)

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Catherine Lee Hough · JOHNS HOPKINS UNIVERSITY · 2024 · $690,643 — Even before COVID-19, pneumonia with respiratory failure was a very common cause of hospitalization. Unfortunately, many patients who survive pneumonia have persistent health problems for months or years afterwards. The objective of this Effective Primary Care Practices that Enhance Recovery Traject…

A Population-Based Latinx Community Study of Alzheimer’s Disease

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Kristin R Krueger · RUSH UNIVERSITY MEDICAL CENTER · 2024 · $516,995 — ABSTRACT Older Latinx adults in the US are at a greater risk of developing Alzheimer's disease (AD) and related dementias (ADRD). They exhibit a faster cognitive decline than non-Hispanic whites. However, they remain vastly underrepresented in research studies to characterize risk factors associated…

Identifying genetic and non-genetic factors influencing susceptibility to infectious diseases in multiple populations

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Samira Asgari · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2024 · $190,125 — Prior research has shown that both environmental factors (e.g., healthcare access, socioeconomic status, and lifestyle) and human genetic variation influence susceptibility to infectious diseases. However, systematic analysis of how both sociodemographic and genetic factors contribute to differences…

AI-Assisted Microendoscopy for the Early Detection of Esophageal Cancer

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Sharmila Anandasabapathy · BAYLOR COLLEGE OF MEDICINE · 2024 · $557,624 — Abstract: Esophageal cancer is the 6th most common cause of cancer-related mortality worldwide. While esophageal squamous cell neoplasia (ESCN) carries a significant global burden, those in certain underserved geographic regions (South America, eastern Africa, eastern Iran, northern China) have part…

Modification of Threat Interpretation Bias to Reduce Anxiety in Neurodegenerative Movement Disorders

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Jessie Sellers Gibson · UNIVERSITY OF VIRGINIA · 2024 · $152,517 — PROJECT SUMMARY: The proposed K23 award will prepare Dr. Jessie Gibson, PhD, RN, AGPCNP-BC to become an independent investigator developing interventions for neuropsychiatric symptom management in neurodegenerative disease. Dr. Gibson’s clinical and research experiences have provided a foundation in…

Assessment of ultrasound-facilitated neurotherapeutics in Alzheimer's disease

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Elisa E. Konofagou · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2024 · $784,859 — Alzheimer’s disease (AD) kills 1 in 3 seniors (more than breast and prostate cancer combined), increased by 16% during the covid-19 pandemic in 2020 and is the costliest condition with an expected $355 billion in healthcare costs in 2021 and $1.1 trillion in 2050. Although some effective treatments …

Scholars in Oncology Associated Research (SOAR)

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

OLUFUNMILAYO F. OLOPADE · UNIVERSITY OF CHICAGO · 2024 · $177,404 — Project Summary/Abstract With the increasing complexity of cancer care, the rising numbers of diverse cancer survivors in the US population, and the increasing global burden of cancer, it is critical that Pritzker School of Medicine (PSOM), one of the most diverse and research-intensive medical scho…

The evolution and genetics of recombination rate variation

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Kieran Samuk · UNIVERSITY OF CALIFORNIA RIVERSIDE · 2024 · $382,958 — PROJECT SUMMARY Meiotic recombination is a fundamental aspect of reproduction in most eukaryotes. Recombination rate, i.e. the number of crossovers per generation, is also a key modulator of genetic and evolutionary processes, having profound effects on basic patterns of genetic inheritance, as well…

Neonatal, Lactation, and Child Health Outcomes Following RSV Vaccination During Pregnancy

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Kristin Palmsten · HEALTHPARTNERS INSTITUTE · 2024 · $732,591 — PROJECT SUMMARY Respiratory Syncytial Virus (RSV) can cause severe illness in young children and is the leading cause of infant hospitalization in the United States. Prenatal RSV prefusion F protein−based (RSVpreF) vaccine efficacy is 69% for severe RSV-associated lower respiratory tract illness in …